Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response

被引：0
作者：
Alamilla-Presuel, Juan C. [1 ,2 ]
机构：
[1] Univ Malaga, Malaga, Spain
[2] Univ Malaga, Med Fac, Dept Radiol & Phys Med, Malaga, Spain
来源：
INTERNATIONAL JOURNAL OF BIOMEDICINE | 2023年 / 13卷 / 03期
关键词：
p53; cancer stem cells; cellular senescence; radioresistance; WILD-TYPE P53; BREAST-CANCER; DNA-DAMAGE; CARCINOMA-CELLS; MUTANT P53; PREDICTS PROGNOSIS; GLUT-1; EXPRESSION; GASTRIC-CANCER; CYCLE ARREST; INHIBITION;
D O I：
10.21103/Article13(3)_RA3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Currently, radiotherapy has been identified as the most common cancer treatment. However, the efficacy of this treatment modality is low in several malignancies due to the resistance of cancer to radiation. Multiple mechanisms, including cell-cycle checkpoint function, DNA repair, and cell death pathways, modulate the radio-responsiveness of cancer cells. This review considered the role of p53, cancer stem cells (CSCs), and cellular senescence in radiation response.(International Journal of Biomedicine. 2023;13(3):31-45.)
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页码：31 / 45
页数：15
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