Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response

被引：0
作者：
Alamilla-Presuel, Juan C. [1 ,2 ]
机构：
[1] Univ Malaga, Malaga, Spain
[2] Univ Malaga, Med Fac, Dept Radiol & Phys Med, Malaga, Spain
来源：
INTERNATIONAL JOURNAL OF BIOMEDICINE | 2023年 / 13卷 / 03期
关键词：
p53; cancer stem cells; cellular senescence; radioresistance; WILD-TYPE P53; BREAST-CANCER; DNA-DAMAGE; CARCINOMA-CELLS; MUTANT P53; PREDICTS PROGNOSIS; GLUT-1; EXPRESSION; GASTRIC-CANCER; CYCLE ARREST; INHIBITION;
D O I：
10.21103/Article13(3)_RA3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Currently, radiotherapy has been identified as the most common cancer treatment. However, the efficacy of this treatment modality is low in several malignancies due to the resistance of cancer to radiation. Multiple mechanisms, including cell-cycle checkpoint function, DNA repair, and cell death pathways, modulate the radio-responsiveness of cancer cells. This review considered the role of p53, cancer stem cells (CSCs), and cellular senescence in radiation response.(International Journal of Biomedicine. 2023;13(3):31-45.)
引用
收藏
页码：31 / 45
页数：15
相关论文
共 168 条
  • [31] Human mesenchymal stem cells enhance the systemic effects of radiotherapy
    de Araujo Farias, Virginea
    O'Valle, Francisco
    Alonso Lerma, Borja
    Ruiz de Almodovar, Carmen
    Lopez-Penalver, Jesus J.
    Nieto, Ana
    Santos, Ana
    Irene Fernandez, Beatriz
    Guerra-Librero, Ana
    Carmen Ruiz-Ruiz, Maria
    Guirado, Damian
    Schmidt, Thomas
    Javier Oliver, Francisco
    Ruiz de Almodovar, Jose Mariano
    [J]. ONCOTARGET, 2015, 6 (31) : 31164 - 31180
  • [32] NRF2 and the Hallmarks of Cancer
    de la Vega, Montserrat Rojo
    Chapman, Eli
    Zhang, Donna D.
    [J]. CANCER CELL, 2018, 34 (01) : 21 - 43
  • [33] Understanding the limitations of radiation-induced cell cycle checkpoints
    Deckbar, Dorothee
    Jeggo, Penny A.
    Loebrich, Markus
    [J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 46 (04) : 271 - 283
  • [34] Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen
    Demetriou, Stephanie K.
    Ona-Vu, Katherine
    Sullivan, Erin M.
    Dong, Tiffany K.
    Hsu, Shu-Wei
    Oh, Dennis H.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (08) : 1818 - 1827
  • [35] Selective Targeting of the G2/M Cell Cycle Checkpoint to Improve the Therapeutic Index of Radiotherapy
    Dillon, M. T.
    Good, J. S.
    Harrington, K. J.
    [J]. CLINICAL ONCOLOGY, 2014, 26 (05) : 257 - 265
  • [36] Characterization of SHP-1 protein tyrosine phosphatase transcripts, protein isoforms and phosphatase activity in epithelial cancer cells
    Evren, Sevan
    Wan, Simmy
    Ma, Xue-Zhong
    Fahim, Soad
    Mody, Nayha
    Sakac, Darinka
    Jin, Tianru
    Branch, Donald R.
    [J]. GENOMICS, 2013, 102 (5-6) : 491 - 499
  • [37] Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway
    Fabris, L.
    Berton, S.
    Citron, F.
    D'Andrea, S.
    Segatto, I.
    Nicoloso, M. S.
    Massarut, S.
    Armenia, J.
    Zafarana, G.
    Rossi, S.
    Ivan, C.
    Perin, T.
    Vaidya, J. S.
    Avanzo, M.
    Roncadin, M.
    Schiappacassi, M.
    Bristow, R. G.
    Calin, G.
    Baldassarre, G.
    Belletti, B.
    [J]. ONCOGENE, 2016, 35 (37) : 4914 - 4926
  • [38] p53 expression and subcellular survivin localization improve the diagnosis and prognosis of patients with diffuse astrocytic tumors
    Faccion, Roberta Soares
    Bernardo, Paula Sabbo
    Faria de Lopes, Giselle Pinto
    Bastos, Leonardo Soares
    Teixeira, Cristina Lordello
    de Oliveira, Jose Antonio
    Fernandes, Priscila Valverde
    Dubois, Luiz Gustavo
    Chimelli, Leila
    Maia, Raquel Ciuvalschi
    [J]. CELLULAR ONCOLOGY, 2018, 41 (02) : 141 - 157
  • [39] Fan XY, 2019, AM J TRANSL RES, V11, P3543
  • [40] Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization
    Farhood, B.
    Goradel, N. H.
    Mortezaee, K.
    Khanlarkhani, N.
    Salehi, E.
    Nashtaei, M. S.
    Mirtavoos-mahyari, H.
    Motevaseli, E.
    Shabeeb, D.
    Musa, A. E.
    Najafi, M.
    [J]. CLINICAL & TRANSLATIONAL ONCOLOGY, 2019, 21 (03) : 268 - 279
12345678910