tRNA-derived small RNAs: A Novel Regulatory Small Non-coding RNA in renal diseases

被引：2

作者：

Li, Dan ^{[1
,2
]}

Xie, Xian ^{[1
,2
]}

Yin, Ni ^{[1
,2
]}

Wu, Xueqin ^{[1
,2
]}

Yi, Bin ^{[1
,2
]}

Zhang, Hao ^{[1
,2
,4
]}

Zhang, Wei ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China

[2] Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

来源：

KIDNEY DISEASES | 2024年 / 10卷 / 01期

关键词：

tRNA-derived fragments; tRNA-derived stress-induced RNA; renal; GENE-EXPRESSION; POTENTIAL ROLES; TRANSLATIONAL CONTROL; STRESS GRANULES; FRAGMENTS; IDENTIFICATION; PODOCYTE; PROGRESSION; INDICATOR; PROFILES;

D O I：

10.1159/000533811

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small non-coding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including regulation of mRNA stability, transcription, translation, direct interaction with proteins and as epigenetic factors, etc. Recent studies have shown that tsRNAs are also closely related to renal disease. In clinical acute kidney injury (AKI) patients and pre-clinical AKI models, the production and differential expression of tsRNAs in renal tissue and plasma were observed. Decreased expression of tsRNAs was also found in urine exosomes from chronic kidney disease (CKD) patients. Dysregulation of tsRNAs also appears in models of nephrotic syndrome and patients with lupus nephritis (LN). And specific tsRNAs were found in high glucose model in vitro and in serum of diabetic nephropathy (DN) patients. In addition, tsRNAs were also differentially expressed in patients with kidney cancer and transplantation. Key Messages: In the present review, we have summarized up to date works and reviewed the relationship and possible mechanisms between tsRNAs and kidney diseases.

引用

页码：1 / 11

页数：11

共 111 条

[41] Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics [J].