Comparison of the performance of currently used estimated glomerular filtration rate equations with 24-hour urine creatinine clearance: sample analysis of randomised controlled trial participants

被引：1

作者：

Hwang, Jin Ho ^{[1
,2
,3
]}

Oh, Sohee ^{[4
]}

Chin, Ho Jun ^{[5
,6
]}

Kim, Sejoong ^{[5
,6
]}

Kim, Dong Ki ^{[6
,7
]}

Kim, Suhnggwon ^{[8
]}

Park, Jung Hwan ^{[9
,10
]}

Shin, Sung Joon ^{[11
,12
]}

Lee, Sang-Ho ^{[13
,14
]}

Choi, Bum Soon ^{[15
,16
]}

Lim, Chun Soo ^{[5
,6
,17
]}

机构：

[1] Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea

[2] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[3] Grad Sch Med, Seoul, South Korea

[4] Seoul Natl Univ, Dept Biostat, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea

[5] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea

[6] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[7] Seoul Natl Univ, Boramae Hosp, Dept Internal Med, Seoul, South Korea

[8] Seoul K Clin, Seoul, South Korea

[9] Konkuk Univ Hosp Seoul, Dept Internal Med, Seoul, South Korea

[10] Konkuk Univ, Dept Internal Med, Sch Med, Chungju, South Korea

[11] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Goyang 410773, South Korea

[12] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea

[13] Kyung Hee Univ, Dept Internal Med, Med Ctr, Seoul, South Korea

[14] Kyung Hee Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[15] Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea

[16] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea

[17] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea

来源：

BMJ OPEN | 2023年 / 13卷 / 08期

关键词：

chronic renal failure; nephrology; adult nephrology; CKD-EPI EQUATION; SERUM CREATININE; RENAL-DISEASE; KIDNEY-FUNCTION; DIET; PREVALENCE;

D O I：

10.1136/bmjopen-2022-067398

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective There are several equations for estimating the glomerular filtration rate (GFR), and each method has its limitations. We compared various estimated GFR (eGFR) equations with 24 hours urine creatinine clearance (24u-CCr).Design Sample analysis of randomised controlled trial participants.Setting and participants We compared the mean 24u-CCr values measured 2-3 times for 211 patients with eGFR values calculated using the following equations: isotope dilution mass spectrometry-Modification of Diet in Renal Disease (IDMS-MDRD) equation, Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation, equations for Koreans (KOR-IDMS-MDRD and KOR-CKD-EPI) and full age spectrum equation.Outcome measures Performance of various creatinine-based eGFR equations, including those with Korean coefficients, compared with the results of the 24u-CCr.Results IDMS-MDRD showed the best overall correlation with the 24u-CCr (R=0.949, p<0.001), and KOR-CKD-EPI showed the best agreement in terms of the intraclass correlation coefficient (ICC, 0.969, 95% CI 0.959 to 0.976, p<0.001). In subgroup analysis, IDMS-MDRD-GFR showed the highest ICCs in CKD stages 1 and 3 (ICC 0.872 in stage 1 and 0.927 in CKD stage 3, all p<0.001). KOR-CKD-EPI showed the highest ICC in CKD stage 2 (ICC 0.854, p<0.001). Overall, the accuracy of CKD-EPI (2021) was the highest at P15 (15%) and P30 (30%) (P15: 65.4 and P30: 97.6). In addition, CKD-EPI (2021) showed the highest P30 accuracy in CKD stage 1 (98.7), whereas KOR-IDMS-MDRD showed the highest P30 accuracy in CKD stages 2 and 3 (98.8 and 98.2, respectively).Conclusions The IDMS-MDRD equation showed the best correlation and overall good agreement with the 24u-CCr; however, the accuracy was low. The most accurate measurements were obtained using the CKD-EPI (2021) equation in CKD stage 1 and the KOR-IDMS-MDRD equation in CKD stages 2-3; nevertheless, the CKD-EPI (2021) equation showed the best overall accuracy.

引用

页数：8

共 5 条

[1] Concordance in critical patients between the equations designed for the calculation of glomerular filtration rate and 24-hour creatinine clearance
Seller-Perez, G.
Herrera-Gutierrez, M. E.
Banderas-Bravo, E.
Olalla-Sanchez, R.
Lozano-Saez, R.
Quesada-Garcia, G.
MEDICINA INTENSIVA, 2010, 34 (05) : 294 - 302
[2] Comparison of Three Glomerular Filtration Rate Estimating Equations with 24-Hour Urine Creatinine Clearance Measurement in Potential Living Kidney Donors
Giron-Luque, Fernando
Garcia-Lopez, Andrea
Baez-Suarez, Yenny
Patino-Jaramillo, Nasly
INTERNATIONAL JOURNAL OF NEPHROLOGY, 2023, 2023
[3] Comparison of 12-Hour Creatinine Clearance and Estimated Glomerular Filtration Rate in Renal Transplant Recipients
Kumar, Rakesh
Pendyala, Prashant
Attwood, Kris
Gray, Vanessa
Venuto, Rocco
Tornatore, Kathleen
RENAL FAILURE, 2013, 35 (03) : 333 - 337
[4] Accuracy of the methods used to estimate glomerular filtration rate compared to 24-hour urinary creatinine clearance in patients with chronic spinal cord injury
Hazer, Burcu
Onder, Fatih Oguz
Metli, Neslihan Bilge
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JOURNAL OF SPINAL CORD MEDICINE, 2023, 46 (02) : 231 - 236
[5] Glomerular filtration rate correlation and agreement between common predictive equations and standard 24-hour urinary creatinine clearance in medical critically ill patients
Wongpraphairot, Suwikran
Thongrueang, Attamon
Bhurayanontachai, Rungsun
PEERJ, 2022, 10

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