Photodynamic Therapy for Colorectal Cancer: An Update and a Look to the Future

被引:24
作者
Rodrigues, Jose A. [1 ,2 ]
Correia, Jose H. [1 ,2 ]
机构
[1] Univ Minho, CMEMS UMinho, P-4800058 Guimaraes, Portugal
[2] LABBELS Associate Lab, P-4800122 Braga, Portugal
关键词
photodynamic therapy; colorectal cancer; photosensitizers; light sources; combination therapies; nanotechnology; ANAL INTRAEPITHELIAL NEOPLASIA; COLON-CANCER; IN-VITRO; CHECKPOINT BLOCKADE; ANIMAL-MODELS; CELLS; PHOTOSENSITIZER; CHLORIN; NANOPARTICLES; PORPHYRIN;
D O I
10.3390/ijms241512204
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review provides an update on the current state of photodynamic therapy (PDT) for colorectal cancer (CRC) and explores potential future directions in this field. PDT has emerged as a promising minimally invasive treatment modality that utilizes photosensitizers and specific light wavelengths to induce cell death in targeted tumor tissues. In recent years, significant progress has been made in understanding the underlying mechanisms, optimizing treatment protocols, and improving the efficacy of PDT for CRC. This article highlights key advancements in PDT techniques, including novel photosensitizers, light sources, and delivery methods. Furthermore, it discusses ongoing research efforts and potential future directions, such as combination therapies and nanotechnology-based approaches. By elucidating the current landscape and providing insights into future directions, this review aims to guide researchers and clinicians in harnessing the full potential of PDT for the effective management of CRC.
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页数:21
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