Oxidative Cleavage and Fluoromethylthiolation of CC Bonds: A General Route toward Mono-, Di-, and Trifluoromethylthioesters from Alkenes

被引：3
作者：
Kou, Li-Gang [1 ]
Guo, Shi-Huan [2 ]
Gao, Ya-Ru [1 ]
Yue, Tianli [2 ]
Wang, Yong-Qiang [1 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Xian 710127, Peoples R China
[2] Northwest Univ, Coll Food Sci & Technol, Res Ctr Food Safety Risk Assessment & Control, Lab Nutr & Hlth Food Individuat Mfg Engn, Xian 710127, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 32期
基金：
中国国家自然科学基金;
关键词：
SUBSTITUENT CONSTANTS; CARBOXYLIC-ACIDS; DIFLUOROMETHYLTHIOLATION; CATALYSIS; CARBONYL; EFFICACY; OLEFINS; ALKYNES; ESTERS;
D O I：
10.1021/acs.orglett.3c02101
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel oxidative cleavage and fluoromethylthiolationreactionof C C bonds has been developed that represents the first andgeneral method for the preparation of mono-, di-, and trifluoromethylthioestersfrom alkenes. The protocol features excellent product selectivityand substrate suitability. Various observations suggested that theprotocol proceeded via a two-step radical process and that aldehydewas the key intermediate. What's more meaningful is that thisroute provides a new direction for converting alkenes into higher-value-addedcarbonyl-containing chemicals.
引用
收藏
页码：5984 / 5988
页数：5
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