Podophyllotoxin derivatives targeting tubulin: An update (2017-2022)

被引：11

作者：

Xu, Yuqin ^{[1
,2
]}

He, Zihan ^{[1
,2
]}

Chen, Li ^{[3
]}

Wang, Huai ^{[1
,2
]}

机构：

[1] Nanchang Univ, Sch Publ Hlth, 461 Ba Yi Ave, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, Jiangxi Prov Key Lab Prevent Med, 461 Ba Yi Ave, Nanchang 330006, Jiangxi, Peoples R China

[3] Hubei Prov Ctr Dis Control & Prevent, 35 Zhuo Daoquan North Rd, Wuhan 430079, Hubei, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 08期

基金：

中国国家自然科学基金;

关键词：

podophyllotoxin derivatives; tubulin; antitumor activity; mode of action; signaling pathways; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; ANTICANCER ACTIVITY; DESIGN; COLCHICINE; AGENTS; MODULATION; INHIBITORS; DISCOVERY; CANDIDATE;

D O I：

10.1016/j.drudis.2023.103640

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous tubulin-targeted podophyllotoxin congeners have been designed and synthesized to overcome the poor water solubility of podophyllotoxin and improve its pharmaceutical characteristics. Understanding the interaction of tubulin with its downstream signal transduction pathways is important for insights into the role of tubulin in the anticancer action of podophyllotoxin-based conjugates. In this review, we provide a detailed account of recent advances in tubulin targetingpodophyllotoxin derivatives with a focus on their antitumor action and potential molecular signaling pathways directly involved in tubulin depolymerization. Such information will be of benefit to researchers designing and developing anticancer drugs derived from podophyllotoxin. Moreover, we also discuss the associated challenges and future opportunities in this field.

引用

页数：11

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