Research gaps and opportunities in autoimmune hepatitis-Results of the international autoimmune hepatitis group research workshop 2022

被引:9
作者
Snijders, Romee J. A. L. M. N. [1 ]
Assis, David H. [2 ]
Oo, Ye [3 ,4 ]
Sebode, Marcial [5 ]
Taubert, Richard [6 ]
Willemse, Jose [7 ]
Tomsin, Bert W. [7 ]
Lohse, Ansgar [5 ]
Drenth, Joost P. H. [1 ]
Gevers, Tom J. G. [8 ,9 ]
机构
[1] Radboud Univ Nijmegen, Dept Gastroenterol & Hepatol, Med Ctr, Nijmegen, Netherlands
[2] Yale Sch Med, Dept Med, Sect Digest Dis, New Haven, CT USA
[3] Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Hosp, Liver Transplant & Hepatobiliary Unit, Birmingham, England
[4] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver & Gastro Res, NIHR Biomed Res Ctr, Birmingham, England
[5] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany
[6] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany
[7] Dutch Liver Patients Assoc, Hoogland, Netherlands
[8] MUMC, Dept Gastroenterol & Hepatol, Maastricht, Netherlands
[9] Maastricht Univ, Nutrim Sch Nutr & Translat Res Metab, Maastricht, Netherlands
关键词
autoimmune hepatitis; clinical trials; diagnostics; quality of life; treatment; unmet needs; MYCOPHENOLATE-MOFETIL; DIAGNOSIS; EFFICACY; CRITERIA; THERAPY; MANAGEMENT; 2ND-LINE; DISEASE; SAFETY;
D O I
10.1111/liv.15573
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Autoimmune hepatitis (AIH) is a rare autoimmune liver disease that is characterised by a chronic inflammatory immune reaction directed against hepatocytes. The disease results in a substantial reduction in quality of life and potentially leads to liver-related complications or death. The International Autoimmune Hepatitis Group (IAIHG) initiated a series of research workshops to uncover the scientific gaps and opportunities in AIH. This review summarises the results of the latest workshop in Maastricht in 2022 and reviews the current challenges in adult AIH, particularly in relation to four important aspects of AIH: diagnostics; new immunomodulatory therapies; clinical trial design; and unmet clinical needs. This review also summarises the progress made since the AIH workshop in 2017. Patients and patient representatives were actively involved in the parallel working groups alongside clinicians and researchers. Despite 40 years of experience with diagnosing and treating AIH, false diagnoses occur and treatment is still based on nonselective immunosuppression. In addition to the need for more specific diagnostic tests, prognostic markers and tailor-based treatments, a major unmet clinical need was identified in areas of care delivery and health-related quality of life.
引用
收藏
页码:1375 / 1384
页数:10
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