Challenges in the Diagnosis of Parathyroid Cancer: Unraveling the Diagnostic Maze

被引:0
作者
Stanciu, Mihaela [1 ,2 ]
Cipaian, Remus Calin [3 ]
Ristea, Ruxandra [1 ,2 ]
Vasile, Corina Maria [4 ]
Popescu, Mihaela [5 ]
Popa, Florina Ligia [6 ,7 ]
机构
[1] Cty Clin Emergency Hosp Sibiu, Dept Endocrinol, Sibiu 550245, Romania
[2] Lucian Blaga Univ Sibiu, Fac Med, Dept Endocrinol, Sibiu 550169, Romania
[3] Lucian Blaga Univ Sibiu, Fac Med, Dept Internal Med, Sibiu 550169, Romania
[4] Bordeaux Univ Hosp, Dept Pediat & Adult Congenital Cardiol, F-33600 Pessac, France
[5] Univ Med & Pharm Craiova, Dept Endocrinol, Craiova 200349, Romania
[6] Lucian Blaga Univ Sibiu, Fac Med, Dept Phys Med & Rehabil, Sibiu 550169, Romania
[7] Cty Clin Emergency Hosp Sibiu, Dept Phys Med & Rehabil, Sibiu 550245, Romania
关键词
parathyroid carcinoma; parathyroid hormone; early diagnosis; CARCINOMA CHALLENGES; HRPT2; GENE; MUTATIONS; FEATURES; ADENOMA;
D O I
10.3390/reports6030040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Parathyroid carcinoma (PC) is a rare and aggressive cancer affecting the parathyroid glands, presenting diagnostic and therapeutic challenges due to its rarity and overlapping features with benign parathyroid disease. This report describes the case of a 51-year-old patient with significantly elevated serum calcium levels, leading to further investigation. Imaging studies revealed a large nodular mass in the right inferior parathyroid gland. After undergoing right inferior parathyroidectomy, pathology confirmed parathyroid carcinoma. However, the patient experienced a relapse, detected via a neck MRI. This case highlights the importance of specific clinical features, such as rapid calcium increase, elevated parathyroid hormone (PTH) levels, and a large nodular mass, in suspecting malignancy. Differential diagnosis between carcinoma and adenoma can be challenging, and immunohistochemistry aids in diagnosis. Regular follow-up with calcium and PTH monitoring is essential for detecting recurrence. This case underscores the aggressive nature of parathyroid carcinoma and the importance of early diagnosis, surgical intervention, and thorough follow-up care for improved outcomes.
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页数:10
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