The Role of Mesenchymal Stem Cells in Cancer Immunotherapy

被引：4

作者：

Zhao, Yueshui ^{[1
,2
]}

Zhong, Xianmei ^{[1
,2
,9
]}

Du, Fukuan ^{[1
,2
]}

Wu, Xu ^{[1
,2
]}

Li, Mingxing ^{[1
,2
]}

Wen, Qinglian ^{[3
]}

Shen, Jing ^{[1
,2
]}

Chen, Yu ^{[1
,2
]}

Zhang, Xinyi ^{[4
]}

Yang, Zhongming ^{[5
]}

Deng, Ying ^{[6
]}

Liu, Xiang ^{[6
]}

Zou, Chang ^{[7
]}

Du, Yu ^{[6
]}

Xiao, Zhangang ^{[1
,8
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China

[2] South Sichuan Inst Translat Med, Luzhou, Sichuan, Peoples R China

[3] Southwest Med Univ, Dept Oncol, Affiliated Hosp, Luzhou, Sichuan, Peoples R China

[4] Chinese Univ Hong Kong, Sch Data Sci, Shenzhen, Peoples R China

[5] Affiliated Tradit Chinese Med Hosp Southwest Med U, Dept Oncol & Hematol, Luzhou, Sichuan, Peoples R China

[6] Southwest Med Univ, Med Cosmetol Ctr, Affiliated Tradit Chinese Med, Luzhou, Sichuan, Peoples R China

[7] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Res Ctr, Clin Med Coll 2, Shenzhen, Peoples R China

[8] Cell Therapy & Cell Drugs Luzhou Key Lab, Luzhou, Sichuan, Peoples R China

[9] Peoples Hosp Nanbu Cty, Dept Pharm, Nanchong, Sichuan, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2023年 / 18卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Mesenchymal stem cells; tumor; cancer immunotherapy; cytokine storm; chimeric antigen receptor; cellular immune cell therapy (CAR-T); GENE DELIVERY; IN-VITRO; TUMOR; THERAPY; GROWTH; INTERLEUKIN-12; VEHICLES; IMMUNOGENICITY; METASTASIS; EXPRESSION;

D O I：

10.2174/1574888X18666230103120302

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are getting attention in the field of cancer immunotherapy. The main effects of MSCs on tumors are homing and regulation of inflammatory and immune responses. Indeed, cancer immunotherapy has become a promising treatment and MSCs play a potential role in regulating the efficacy of immunotherapy. In addition, MSCs are an ideal carrier for immunomodulatory protein transmission. As such MSCs combined with immunotherapy drugs could act synergistically against tumors, throwing a great impact on cancer therapy. And MSCs may have potential in the treatment of cytokine storm or cytokine release syndrome (CRS). It is assumed that MSCs can form chimeric antigen receptor MSCs (CAR-MSCs). Whether CAR-MSCs can provide a new idea of cancer immunotherapy is unknown. It is a prime time to review the latest progress of MSCs in cancer immunotherapy, in order to clarify to fully understand the role of MSCs in cancer therapy in clinical practice.

引用

页码：1056 / 1068

页数：13

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