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The potential of the use of deep eutectic solvents and amino acid-based ionic liquids to enhance the chiral discrimination ability of different chiral selectors in capillary electrophoresis
被引:19
|作者:
Ioannou, Katerina A.
[1
]
Ioannou, Georgia D.
[1
]
Christou, Atalanti
[1
]
Stavrou, Ioannis J.
[2
]
Schmid, Martin G.
[3
]
Kapnissi-Christodoulou, Constantina P.
[1
]
机构:
[1] Univ Cyprus, Dept Chem, CY-1678 Nicosia, Cyprus
[2] European Univ Cyprus, Dept Life Sci, CY-2404 Nicosia, Cyprus
[3] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmaceut Chem, A-8010 Graz, Austria
关键词:
Amino acid -based ionic liquids;
Deep eutectic solvents;
Cyclodextrin;
Cyclofructan;
Amphetamine derivatives;
CYCLOINULO-OLIGOSACCHARIDE;
SEPARATION;
CYCLODEXTRIN;
DERIVATIVES;
ENANTIOSEPARATION;
CYCLOFRUCTANS;
AMPHETAMINES;
COMPLEXES;
PROFILES;
SYSTEM;
D O I:
10.1016/j.chroma.2023.464152
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
The effect of the combined use of amino acid-based ionic liquids (AAILs) and deep eutectic solvents (DESs) with either cyclodextrin-(CD) or cyclofructan-(CF) based chiral selectors for the chiral separa-tion of amphetamine derivatives was investigated in the present study. A non-significant improvement in enantiomeric separation of target analytes was observed when AAILs were combined with either CF or CD. On the other side, a markedly improved chiral separation of enantiomers was obtained using the dual carboxymethyl-& beta;-cyclodextrin/DES system, highlighting the existence of a synergistic effect. After the addition of 0.5% v/v of choline chloride-ethylene glycol, the resolution of the enantiomers of am-phetamine, methamphetamine and 3-fluorethamphetamine, increased from 1.4, 1.1, 1.0 to 1.8, 1.8, and 1.5 min, and the analysis times increased from 19.54, 20.48, 18.71 to 35.71, 35.78 and 32.90 min, re-spectively. This was not the case for the CF/DES dual system, in which the separation of amphetamines worsened, indicating an antagonistic effect. In conclusion, DESs are a very promising additive in capil-lary electrophoresis that can improve the separation of chiral molecules in combination with CDs but not CFs. & COPY; 2023 Elsevier B.V. All rights reserved.
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