The potential of the use of deep eutectic solvents and amino acid-based ionic liquids to enhance the chiral discrimination ability of different chiral selectors in capillary electrophoresis

被引:19
|
作者
Ioannou, Katerina A. [1 ]
Ioannou, Georgia D. [1 ]
Christou, Atalanti [1 ]
Stavrou, Ioannis J. [2 ]
Schmid, Martin G. [3 ]
Kapnissi-Christodoulou, Constantina P. [1 ]
机构
[1] Univ Cyprus, Dept Chem, CY-1678 Nicosia, Cyprus
[2] European Univ Cyprus, Dept Life Sci, CY-2404 Nicosia, Cyprus
[3] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmaceut Chem, A-8010 Graz, Austria
关键词
Amino acid -based ionic liquids; Deep eutectic solvents; Cyclodextrin; Cyclofructan; Amphetamine derivatives; CYCLOINULO-OLIGOSACCHARIDE; SEPARATION; CYCLODEXTRIN; DERIVATIVES; ENANTIOSEPARATION; CYCLOFRUCTANS; AMPHETAMINES; COMPLEXES; PROFILES; SYSTEM;
D O I
10.1016/j.chroma.2023.464152
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The effect of the combined use of amino acid-based ionic liquids (AAILs) and deep eutectic solvents (DESs) with either cyclodextrin-(CD) or cyclofructan-(CF) based chiral selectors for the chiral separa-tion of amphetamine derivatives was investigated in the present study. A non-significant improvement in enantiomeric separation of target analytes was observed when AAILs were combined with either CF or CD. On the other side, a markedly improved chiral separation of enantiomers was obtained using the dual carboxymethyl-& beta;-cyclodextrin/DES system, highlighting the existence of a synergistic effect. After the addition of 0.5% v/v of choline chloride-ethylene glycol, the resolution of the enantiomers of am-phetamine, methamphetamine and 3-fluorethamphetamine, increased from 1.4, 1.1, 1.0 to 1.8, 1.8, and 1.5 min, and the analysis times increased from 19.54, 20.48, 18.71 to 35.71, 35.78 and 32.90 min, re-spectively. This was not the case for the CF/DES dual system, in which the separation of amphetamines worsened, indicating an antagonistic effect. In conclusion, DESs are a very promising additive in capil-lary electrophoresis that can improve the separation of chiral molecules in combination with CDs but not CFs. & COPY; 2023 Elsevier B.V. All rights reserved.
引用
收藏
页数:9
相关论文
共 31 条
  • [21] Amino-(3-cyclodextrin derivatives with different chain lengths as chiral selectors for separation of dansyl amino acid enantiomers by capillary electrophoresis
    Fu, Yuanyuan
    Jiang, Min
    Chen, Zilin
    JOURNAL OF CHROMATOGRAPHY A, 2025, 1746
  • [22] Application of amino acid-based natural deep eutectic solvents in extraction of different analytes: A review study
    Dehaghani, Mansoureh Sadat Taghavi
    Esfandiari, Zahra
    Rostamabadi, Hadis
    Nodeh, Hamid Rashidi
    TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2024, 147
  • [23] Visual chiral recognition of aromatic amino acids with (S)-mandelic acid-based ionic liquids via complexation
    Ma, Xiaofei
    Du, Yingxiang
    Zhu, Xinqi
    Yang, Jiangxia
    TALANTA, 2020, 217
  • [24] Evaluation of chiral separation ability and separation principle of /3-cyclodextrins-based supramolecular deep eutectic solvent in capillary electrophoresis
    Liu, Yongjing
    Huang, Dongting
    Zhuo, Chenxi
    Guo, Min
    Chen, Lirong
    Chen, Xiaofen
    Li, Hua
    Xu, Wei
    TALANTA, 2025, 283
  • [25] Clindamycin phosphate-based deep eutectic solvent as a chiral selector for enantioseparation of amino alcohol drugs in nonaqueous capillary electrophoresis
    Ma, Xiaofei
    Zhang, Chengchen
    JOURNAL OF CHROMATOGRAPHY A, 2024, 1736
  • [26] Investigation of maltodextrin-based synergistic system with amino acid chiral ionic liquid as additive for enantioseparation in capillary electrophoresis
    Chen, Jiaquan
    Du, Yingxiang
    Sun, Xiaodong
    CHIRALITY, 2017, 29 (12) : 824 - 835
  • [27] Establishment and Molecular Modeling Study of Cyclodextrin-Based Synergistic Enantioseparation Systems with Three New Amino Acid Chiral Ionic Liquids as Additives in Capillary Electrophoresis
    Liu, Jie
    Zhang, Jian
    Zhu, Dongyang
    Zhu, Xinqi
    Du, Yingxiang
    Ma, Xiaofei
    Feng, Zijie
    Sun, Xiaodong
    Xu, Hui
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2022, 60 (10) : 984 - 990
  • [28] Development of new chiral ligand exchange capillary electrophoresis system with amino acid ionic liquids ligands and its application in studying the kinetics of L-amino acid oxidase
    Sun, Bingbing
    Mu, Xiaoyu
    Qi, Li
    ANALYTICA CHIMICA ACTA, 2014, 821 : 97 - 102
  • [29] Evaluation of vancomycin-based synergistic system with amino acid ester chiral ionic liquids as additives for enantioseparation of non-steroidal anti-inflamatory drugs by capillary electrophoresis
    Zhang, Jinjing
    Du, Yingxiang
    Zhang, Qi
    Lei, Yuntao
    TALANTA, 2014, 119 : 193 - 201
  • [30] Establishment and molecular modeling study of maltodextrin-based synergistic enantioseparation systems with two new hydroxy acid chiral ionic liquids as additives in capillary electrophoresis
    Yang, Xuan
    Du, Yingxiang
    Feng, Zijie
    Liu, Zongran
    Li, Jingtang
    JOURNAL OF CHROMATOGRAPHY A, 2018, 1559 : 170 - 177