Targeting NRAS Mutations in Advanced Melanoma

被引：8

作者：

Phadke, Manali S. S. ^{[1
]}

Smalley, Keiran S. M. ^{[1
,2
,3
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Oncol, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, 12902 Magnolia Dr, Tampa, FL 33612 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 41卷 / 14期

关键词：

FEEDBACK INHIBITION; MUTANT; BRAF; MEK; PATHWAY; ERK; RESPONSES; CELLS;

D O I：

10.1200/JCO.23.00205

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：2661 / +

页数：5

共 33 条

[1] TRANSFORMING RAS GENES FROM HUMAN-MELANOMA - A MANIFESTATION OF TUMOR HETEROGENEITY [J].

ALBINO, AP ;

LESTRANGE, R ;

OLIFF, AI ;

FURTH, ME ;

OLD, LJ .

NATURE, 1984, 308 (5954) :69-72

[2] Dual MEK/AKT inhibition with trametinib and GSK2141795 does not yield clinical benefit in metastatic NRAS-mutant and wild-type melanoma [J].

Algazi, Alain P. ;

Esteve-Puig, Rosaura ;

Nosrati, Adi ;

Hinds, Brian ;

Hobbs-Muthukumar, Adele ;

Nandoskar, Prachi ;

Ortiz-Urda, Susana ;

Chapman, Paul B. ;

Daud, Adil .

PIGMENT CELL & MELANOMA RESEARCH, 2018, 31 (01) :110-114

[3] Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma [J].

Atefi, Mohammad ;

Titz, Bjoern ;

Avramis, Earl ;

Ng, Charles ;

Wong, Deborah J. L. ;

Lassen, Amanda ;

Cerniglia, Michael ;

Escuin-Ordinas, Helena ;

Foulad, David ;

Comin-Anduix, Begonya ;

Graeber, Thomas G. ;

Ribas, Antoni .

MOLECULAR CANCER, 2015, 14

[4] Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134 [J].

Atkins, Michael B. ;

Lee, Sandra J. ;

Chmielowski, Bartosz ;

Tarhini, Ahmad A. ;

Cohen, Gary I. ;

Truong, Thach-Giao ;

Moon, Helen H. ;

Davar, Diwakar ;

O'Rourke, Mark ;

Stephenson, Joseph J. ;

Curti, Brendan D. ;

Urba, Walter J. ;

Brell, Joanna M. ;

Funchain, Pauline ;

Kendra, Kari L. ;

Ikeguchi, Alexandra P. ;

Jaslowski, Anthony ;

Bane, Charles L. ;

Taylor, Mark A. ;

Bajaj, Madhuri ;

Conry, Robert M. ;

Ellis, Robert J. ;

Logan, Theodore F. ;

Laudi, Noel ;

Sosman, Jeffrey A. ;

Crockett, David G. ;

Pecora, Andrew L. ;

Okazaki, Ian J. ;

Reganti, Sowjanya ;

Chandra, Sunandana ;

Guild, Samantha ;

Chen, Helen X. ;

Streicher, Howard Z. ;

Wolchok, Jedd D. ;

Ribas, Antoni ;

Kirkwood, John M. .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (02) :186-+

[5] Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling [J].

Bhatt, KV ;

Spofford, LS ;

Aram, G ;

McMullen, M ;

Pumiglia, K ;

Aplin, AE .

ONCOGENE, 2005, 24 (21) :3459-3471

[6] Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival [J].

Cartlidge, Robert A. ;

Thomas, G. R. ;

Cagnol, Sebastien ;

Jong, Kimberly A. ;

Molton, Sarah A. ;

Finch, Andrew J. ;

McMahon, Martin .

PIGMENT CELL & MELANOMA RESEARCH, 2008, 21 (05) :534-544

[7] Initial Evidence for the Efficacy of Naporafenib in Combination With Trametinib in NRAS-Mutant Melanoma: Results From the Expansion Arm of a Phase Ib, Open-Label Study [J].

de Braud, Filippo ;

Dooms, Christophe ;

Heist, Rebecca S. ;

Lebbe, Celeste ;

Wermke, Martin ;

Gazzah, Anas ;

Schadendorf, Dirk ;

Rutkowski, Piotr ;

Wolf, Juergen ;

Ascierto, Paolo A. ;

Gil-Bazo, Ignacio ;

Kato, Shumei ;

Wolodarski, Maria ;

McKean, Meredith ;

Couselo, Eva Munoz ;

Sebastian, Martin ;

Santoro, Armando ;

Cooke, Vesselina ;

Manganelli, Luca ;

Wan, Kitty ;

Gaur, Anil ;

Kim, Jaeyeon ;

Caponigro, Giordano ;

Couillebault, Xuan-Mai ;

Evans, Helen ;

Campbell, Catarina D. ;

Basu, Sumit ;

Moschetta, Michele ;

Daud, Adil .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (14) :2651-+

[8] Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial [J].

Dummer, Reinhard ;

Schadendorf, Dirk ;

Ascierto, Paolo A. ;

Arance, Ana ;

Dutriaux, Caroline ;

Di Giacomo, Anna Maria ;

Rutkowski, Piotr ;

Del Vecchio, Michele ;

Gutzmer, Ralf ;

Mandala, Mario ;

Thomas, Luc ;

Demidov, Lev ;

Garbe, Claus ;

Hogg, David ;

Liszkay, Gabriella ;

Queirolo, Paola ;

Wasserman, Ernesto ;

Ford, James ;

Weill, Marine ;

Sirulnik, L. Andres ;

Jehl, Valentine ;

Bozon, Viviana ;

Long, Georgina V. ;

Flaherty, Keith .

LANCET ONCOLOGY, 2017, 18 (04) :435-445

[9] NRAS mutant melanoma: biological behavior and future strategies for therapeutic management [J].

Fedorenko, I. V. ;

Gibney, G. T. ;

Smalley, K. S. M. .

ONCOGENE, 2013, 32 (25) :3009-3018

[10] Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS-Mutant Melanoma [J].

Haarberg, H. Eirik ;

Paraiso, Kim H. T. ;

Wood, Elizabeth ;

Rebecca, Vito W. ;

Sondak, Vernon K. ;

Koomen, John M. ;

Smalley, Keiran S. M. .

MOLECULAR CANCER THERAPEUTICS, 2013, 12 (06) :901-912

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