Biomedical applications of MnO2 nanomaterials as nanozyme-based theranostics

被引：55
作者：
Sisakhtnezhad, Sajjad [1 ]
Rahimi, Matin [1 ]
Mohammadi, Soheila [2 ]
机构：
[1] Razi Univ, Fac Sci, Dept Biol, Kermanshah, Iran
[2] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷
关键词：
MnO; 2; nanozyme; Colorimetric detection assays; Smart nanosystem; Theranostics effect; Pathological conditions; Cancer; ENHANCED PHOTODYNAMIC THERAPY; OXIDASE-LIKE ACTIVITY; TUMOR-MICROENVIRONMENT; MANGANESE-DIOXIDE; COLORIMETRIC DETECTION; ASCORBIC-ACID; COMBINATION THERAPY; BLADDER-CANCER; LUNG-CANCER; NANOPARTICLES;
D O I：
10.1016/j.biopha.2023.114833
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Manganese dioxide (MnO2) nanoenzymes/nanozymes (MnO2-NEs) are 1-100 nm nanomaterials that mimic catalytic, oxidative, peroxidase, and superoxide dismutase activities. The oxidative-like activity of MnO2-NEs makes them suitable for developing effective and low-cost colorimetric detection assays of biomolecules. Interestingly, MnO2-NEs also demonstrate scavenging properties against reactive oxygen species (ROS) in various pathological conditions. In addition, due to the decomposition of MnO2-NEs in the tumor microenvironment (TME) and the production of Mn2+, they can act as a contrast agent for improving clinical imaging diagnostics. MnO2-NEs also can use as an in situ oxygen production system in TME, thereby overcoming hypoxic conditions and their consequences in the progression of cancer. Furthermore, MnO2-NEs as a shell and coating make the
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页数：17
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