Mas-related G protein-coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review

被引：2

作者：

Hawker, Patrick ^{[1
]}

Zhang, Li ^{[2
]}

Liu, Lu ^{[1
]}

机构：

[1] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia

[2] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2024年 / 181卷 / 14期

关键词：

enteric nervous system; gastrointestinal; inflammation; inflammatory bowel disease; Mas-related G protein-coupled receptor; mast cell; motility; Mrgpr; INTESTINAL EPITHELIAL-CELLS; FACTOR-KAPPA-B; INDUCED COLITIS; CROHNS-DISEASE; NERVOUS-SYSTEM; ULCERATIVE-COLITIS; COLONIC MUCOSA; HOST-DEFENSE; SUBSTANCE-P; ACTIVATION;

D O I：

10.1111/bph.16059

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammatory bowel disease (IBD) is a chronic debilitating condition, hallmarked by persistent inflammation of the gastrointestinal tract. Despite recent advances in clinical treatments, the aetiology of IBD is unknown, and a large proportion of patients are refractory to pharmacotherapy. Understanding IBD immunopathogenesis is crucial to discern the cause of IBD and optimise treatments. Mas-related G protein-coupled receptors (Mrgprs) are a family of approximately 50 G protein-coupled receptors that were first identified over 20 years ago. Originally known for their expression in skin nociceptors and their role in transmitting the sensation of itch in the periphery, new reports have described the presence of Mrgprs in the gastrointestinal tract. In this review, we consider the impact of these findings and assess the evidence that suggests that Mrgprs may be involved in the disrupted homeostatic processes that contribute to gastrointestinal disorders and IBD.

引用

页码：2197 / 2211

页数：15

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