Aging reduces ABHD5 protein content in the adipose tissue of mice: The reversal effect of exercise

被引：0

作者：

Bricola, Rafael S. ^{[1
]}

Cordeiro, Andre, V ^{[1
]}

Crisol, Barbara M. ^{[1
]}

Braga, Renata R. ^{[1
]}

de Melo, Diego G. ^{[1
]}

Rocha, Matheus B. ^{[1
]}

Gaspar, Rafael C. ^{[1
]}

Nakandakari, Susana C. B. R. ^{[2
]}

Silva, Vagner R. R. ^{[1
]}

Anaruma, Chadi P. ^{[1
]}

Katashima, Carlos K. ^{[1
]}

Canciglieri, Raphael D. S. ^{[1
]}

Munoz, Vitor R. ^{[1
]}

Pavan, Isadora C. B. ^{[3
]}

Pinto, Ana P. ^{[4
]}

Simabuco, Fernando M. ^{[3
]}

da Silva, Adelino S. R. ^{[4
]}

Moura, Leandro P. ^{[1
,5
]}

Pauli, Jose R. ^{[1
,5
,6
]}

Cintra, Dennys E. ^{[2
,6
]}

Ropelle, Eduardo R. ^{[1
,5
,6
,7
]}

机构：

[1] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, Limeira, SP, Brazil

[2] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom LabGeN, Limeira, SP, Brazil

[3] Univ Estadual Campinas, Sch Appl Sci, Multidisciplinary Lab Food & Hlth, Limeira, SP, Brazil

[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP, Brazil

[5] Univ Campinas UNICAMP, CEPECE Ctr Res Sport Sci, Sch Appl Sci, Limeira, SP, Brazil

[6] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Lab Cell Signaling, Campinas, SP, Brazil

[7] Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP, Brazil

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2023年 / 41卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

ABHD5; adipose tissue; aging; physical exercise and lipolysis; FAT; LIPOLYSIS;

D O I：

10.1002/cbf.3770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dysfunction of the adipose tissue metabolism is considered as a significant hallmark of aging. It has been proposed that alpha-beta hydrolase domain containing 5 (ABHD5) plays a critical role in the control of lipolysis. However, the role of ABHD5 in the control of lipolysis during aging or exercise is unknown. Here we combined the experimental mouse model with transcriptomic analyzes by using murine and human databases to explore the role of ABHD5 in the adipose tissue during aging and in response to exercise. Transcriptomic data revealed a downregulation of Abhd5 messenger RNA levels in the subcutaneous white adipose tissue (scWAT) over time in individuals from 20 to 69 years old. Aged mice displayed dramatic reduction of ABHD5 protein content and lipolytic-related proteins in the scWAT. Interestingly, 4 weeks of high-intensity interval training increased ABHD5 protein level and restored the lipolytic pathway in the scWAT of aged mice. Altogether, our findings demonstrated that aging affects ABHD5 content in the adipose tissue of mice and humans. Conversely, exercise increases ABHD5 activity, recovering the lipolytic activity in aged mice.

引用

页码：128 / 137

页数：10

共 37 条

[1] The influence of high-intensity interval training on anthropometric variables of adults with overweight or obesity: a systematic review and network meta-analysis [J].

Andreato, L. V. ;

Esteves, J. V. ;

Coimbra, D. R. ;

Moraes, A. J. P. ;

de Carvalho, T. .

OBESITY REVIEWS, 2019, 20 (01) :142-155

[2] Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits [J].

Andreux, Penelope A. ;

Williams, Evan G. ;

Koutnikova, Hana ;

Houtkooper, Riekelt H. ;

Champy, Marie-France ;

Henry, Hugues ;

Schoonjans, Kristina ;

Williams, Robert W. ;

Auwerx, Johan .

CELL, 2012, 150 (06) :1287-1299

[3] Adipose lipid turnover and long-term changes in body weight [J].

Arner, P. ;

Bernard, S. ;

Appelsved, L. ;

Fu, K. -Y. ;

Andersson, D. P. ;

Salehpour, M. ;

Thorell, A. ;

Ryden, M. ;

Spalding, K. L. .

NATURE MEDICINE, 2019, 25 (09) :1385-+

[4] Changes in Visceral Adipose Tissue Plasma Membrane Lipid Composition in Old Rats Are Associated With Adipocyte Hypertrophy With Aging [J].

Bonzon-Kulichenko, Elena ;

Molto, Eduardo ;

Pintado, Cristina ;

Fernandez, Alejandro ;

Arribas, Carmen ;

Schwudke, Dominik ;

Gallardo, Nilda ;

Shevchenko, Andrej ;

Andres, Antonio .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2018, 73 (09) :1139-1146

[5] Critical roles for α/β hydrolase domain 5 (ABHD5)/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond [J].

Brown, Amanda L. ;

Brown, J. Mark .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2017, 1862 (10) :1233-1241

[6] Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis [J].

Camell, Christina D. ;

Guenther, Patrick ;

Lee, Aileen ;

Goldberg, Emily L. ;

Spadaro, Olga ;

Youm, Yun-Hee ;

Bartke, Andrzej ;

Hubbard, Gene B. ;

Ikeno, Yuji ;

Ruddle, Nancy H. ;

Schultze, Joachim ;

Dixit, Vishwa Deep .

CELL METABOLISM, 2019, 30 (06) :1024-+

[7] Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing [J].

Camell, Christina D. ;

Sander, Jil ;

Spadaro, Olga ;

Lee, Aileen ;

Nguyen, Kim Y. ;

Wing, Allison ;

Goldberg, Emily L. ;

Youm, Yun-Hee ;

Brown, Chester W. ;

Elsworth, John ;

Rodeheffer, Matthew S. ;

Schultze, Joachim L. ;

Dixit, Vishwa Deep .

NATURE, 2017, 550 (7674) :119-+

[8] Adipose Triglyceride Lipase Regulation: An Overview [J].

Cerk, Ines Katrin ;

Wechselberger, Lisa ;

Oberer, Monika .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2018, 19 (02) :221-233

[9] IL-6 Regulates Mcl-1L Expression through the JAK/PI3K/Akt/CREB Signaling Pathway in Hepatocytes: Implication of an Anti-Apoptotic Role during Liver Regeneration [J].

Chou, Chia-Hung ;

Lai, Shuo-Lun ;

Chen, Chiung-Nien ;

Lee, Po-Huang ;

Peng, Fu-Chuo ;

Kuo, Min-Liang ;

Lai, Hong-Shiee .

PLOS ONE, 2013, 8 (06)

[10] Exercise Training Reduces Inflammation of Adipose Tissue in the Elderly: Cross-Sectional and Randomized Interventional Trial [J].

Cizkova, Terezie ;

Stepan, Marek ;

Dad'ova, Klara ;

Ondrujova, Barbora ;

Sontakova, Lenka ;

Krauzova, Eva ;

Matous, Milos ;

Koc, Michal ;

Gojda, Jan ;

Kracmerova, Jana ;

Stich, Vladimir ;

Rossmeislova, Lenka ;

Siklova, Michaela .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (12)

← 1 2 3 4 →