Physicochemical properties and mechanism of solubilised neohesperidin system based on inclusion complex of hydroxypropyl-β-cyclodextrin

A solvent method was used to prepare the inclusion compound of neohesperidin (NH) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) to improve the water solubility and thermal stability of NH. The physical and chemical properties and supramolecular structure of the inclusion complex were investigated by UV-vis spectroscopy, FTIR, SEM, TG-DTG, PXRD, NMR and molecular docking techniques. The results showed that the C-ring of NH was embedded in the cavity of HP-beta-CD to form an inclusion complex. The phase has changed significantly, NH is completely dispersed in HP-beta-CD in an amorphous state, and the two are combined in the form of non-covalent bonds such as hydrogen bonds or van der Waals forces. Through inclusion of HP-beta-CD, the solubility of NH in water at 37 degrees C increased from 161.81 mu g ml(-1) to 1927.12 mu g ml(-1), and its stability was also significantly improved.