What is the optimal (neo)adjuvant strategy of extremity high-risk soft tissue sarcomas (ESTS)?

被引：0
作者：
Kharmoum, Saoussane [1 ]
Kharmoum, Jinane [2 ]
Chraibi, Mariam [2 ]
Bonvalot, Sylvie [3 ]
Blay, Jean-yves [4 ]
Shimi, Mohammed [5 ]
机构：
[1] Reg Hosp Ctr, Tangier, Morocco
[2] Abdelmalek Essadi Univ, Univ Hosp Ctr Mohamed VI, Fac Med & Pharm Tangier, Lab Pathol, Tetouan, Morocco
[3] Inst Curie, Dept Surg Oncol, Sarcoma Unit, Paris, France
[4] Univ CI Bernard, Leon Berard Ctr, Dept Med Oncol, Lyon, France
[5] Abdelmalek Essadi Univ, Univ Hosp Ctr Mohamed VI, Fac Med & Pharm Tangier, Trauma Orthoped Dept, Tetouan, Morocco
来源：
MEDICAL ONCOLOGY | 2023年 / 41卷 / 01期
关键词：
Extremity high risk soft tissue sarcomas; Neoadjuvant strategy; Adjuvant therapy; Pathological response; Boost radiotherapy; DOSE ADJUVANT CHEMOTHERAPY; RANDOMIZED CLINICAL-TRIAL; NEOADJUVANT CHEMOTHERAPY; POSTOPERATIVE RADIOTHERAPY; EUROPEAN ORGANIZATION; HIGH-GRADE; SURVIVAL; RADIATION; THERAPY;
D O I：
10.1007/s12032-023-02240-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Currently, the standard treatment for extremity high-risk soft tissue sarcomas (ESTS) combines surgery and pre- or post-op radiation therapy (RT). In some selected cases, chemotherapy (CT) is incorporated into the therapeutic algorithm as a neoadjuvant approach to enable conservative management. Given the risk of local or metastatic relapse, this paper discusses the potential benefits of CT and RT in high-grade ESTs. The role of adjuvant chemotherapy in addition to neoadjuvant CT, the prognostic value of the pathological response to neoadjuvant treatment, and the role for an adjuvant "boost" following resection after pre-operative radiotherapy will be discussed.
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页数：6
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