Delta-radiomics in cancer immunotherapy response prediction: A systematic review

被引：14

作者：

Abbas, Engy ^{[1
]}

Fanni, Salvatore Claudio ^{[2
]}

Bandini, Claudio ^{[2
]}

Francischello, Roberto ^{[2
]}

Febi, Maria ^{[2
]}

Aghakhanyan, Gayane ^{[2
]}

Ambrosini, Ilaria ^{[2
]}

Faggioni, Lorenzo ^{[2
]}

Cioni, Dania ^{[2
]}

Lencioni, Riccardo Antonio ^{[2
]}

Neri, Emanuele ^{[1
,2
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Womens Coll Hosp, Joint Dept Med Imaging,Sinai Hlth Syst, 610 Univ Ave, Toronto, ON M5G 2M9, Canada

[2] Univ Pisa, Dept Translat Res, Acad Radiol, Pisa, Italy

来源：

EUROPEAN JOURNAL OF RADIOLOGY OPEN | 2023年 / 11卷

关键词：

Delta radiomics; Immunotherapy; Radiomics; Oncology; Therapy response evaluation; Radiomics quality score; LUNG-CANCER; CRITERIA; GUIDELINES; PITFALLS; IMAGES;

D O I：

10.1016/j.ejro.2023.100511

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: The new immunotherapies have not only changed the oncological therapeutic approach but have also made it necessary to develop new imaging methods for assessing the response to treatment. Delta radiomics consists of the analysis of radiomic features variation between different medical images, usually before and after therapy.Purpose: This review aims to evaluate the role of delta radiomics in the immunotherapy response assessment.Methods: A systematic search was performed in PubMed, Scopus, and Web Of Science using "delta radiomics AND immunotherapy" as search terms. The included articles' methodological quality was measured using the Radiomics Quality Score (RQS) tool.Results: Thirteen articles were finally included in the systematic review. Overall, the RQS of the included studies ranged from 4 to 17, with a mean RQS total of 11,15 & PLUSMN; 4,18 with a corresponding percentage of 30.98 & PLUSMN; 11.61 %. Eleven articles out of 13 performed imaging at multiple time points. All the included articles performed feature reduction. No study carried out prospective validation, decision curve analysis, or cost-effectiveness analysis.Conclusions: Delta radiomics has been demonstrated useful in evaluating the response in oncologic patients undergoing immunotherapy. The overall quality was found law, due to the lack of prospective design and external validation. Thus, further efforts are needed to bring delta radiomics a step closer to clinical implementation.

引用

页数：8

共 64 条

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