MC4R in Central and Peripheral Systems

被引：6

作者：

Wei, Ran ^{[1
,2
,3
]}

Li, Danjie ^{[1
,2
]}

Jia, Sheng ^{[1
,2
]}

Chen, Yuhong ^{[1
,2
]}

Wang, Jiqiu ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China

[2] Natl Hlth Commiss PR China, Shanghai Natl Ctr Translat Med, Key Lab Endocrine & Metab Dis, Shanghai Natl Clin Res Ctr Metab Dis, Shanghai 200025, Peoples R China

[3] Fudan Univ, Shanghai Peoples Hosp 5, Dept Endocrinol, Shanghai 200240, Peoples R China

来源：

ADVANCED BIOLOGY | 2023年 / 7卷 / 09期

关键词：

endocrine; melanocortin receptor-4; metabolism; obesity; MELANOCORTIN; 4; RECEPTOR; CENTRAL-NERVOUS-SYSTEM; INTRANASAL NEUROPEPTIDE-Y; NEURONAL PRIMARY CILIA; AGOUTI-RELATED PROTEIN; POMC NEURONS; ENERGY-BALANCE; FOOD-INTAKE; FUNCTIONAL-CHARACTERIZATION; DORSOMEDIAL HYPOTHALAMUS;

D O I：

10.1002/adbi.202300035

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Obesity has emerged as a critical and urgent health burden during the current global pandemic. Among multiple genetic causes, melanocortin receptor-4 (MC4R), involved in food intake and energy metabolism regulation through various signaling pathways, has been reported to be the lead genetic factor in severe and early onset obesity and hyperphagia disorders. Most previous studies have illustrated the roles of MC4R signaling in energy intake versus expenditure in the central system, while some evidence indicates that MC4R is also expressed in peripheral systems, such as the gut and endocrine organs. However, its physiopathological function remains poorly defined. This review aims to depict the central and peripheral roles of MC4R in energy metabolism and endocrine hormone homeostasis, the diversity of phenotypes, biased downstream signaling caused by distinct MC4R mutations, and current drug development targeting the receptor.

引用

页数：15

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