Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface

被引：15

作者：

Buttigieg, Marco M. ^{[1
]}

Rauh, Michael J. ^{[1
,2
]}

机构：

[1] Queens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada

[2] Queens Univ, Richardson Lab, 201F,88 Stuart St, Kingston, ON K7L 3N6, Canada

来源：

JCO PRECISION ONCOLOGY | 2023年 / 7卷

基金：

加拿大健康研究院;

关键词：

COLORECTAL-CANCER; SOMATIC MUTATIONS; TET2; RISK; INFLAMMATION; DNA; ENVIRONMENT; EVOLUTION; DNMT3A; COMMON;

D O I：

10.1200/PO.23.00132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have differential associations with incident and prevalent cancers and their outcomes. Increasing recognition and deeper understanding of genetic subtypes of CH are yielding insights into the tumor-immune interface that may help to explain the heterogeneous impact of CH on tumorigenesis and treatment. Herein, we update the expanding influence of CH in precision oncology and propose important research and clinical questions to address to effectively manage and harness CH in oncology patients.

引用

页数：8

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