Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

被引：3
作者：
Fang, Xian-long [1 ]
Cao, Xue-ping [1 ]
Xiao, Jun [2 ]
Hu, Yun [1 ]
Chen, Mian [1 ]
Raza, Hafiz Khuram [1 ]
Wang, Huai-yuan [3 ]
He, Xu [4 ]
Gu, Jin-fa [1 ]
Zhang, Kang-jian [1 ,2 ,3 ,5 ]
机构：
[1] Shanghai Yuansong Biotechnol Ltd Co, Academician Expert Workstat Fengxian Dist, Shanghai, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol, Shanghai, Peoples R China
[3] Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Inst Smart Biomed Mat, Hangzhou, Peoples R China
[4] Fudan Univ, Huashan Hosp, Dept Stomatol, Shanghai, Peoples R China
[5] Shanghai Yuansong Biotechnol Co ltd, Academician Expert Workstat Fengxian Dist, 1588 Huhang Rd, Shanghai 201499, Peoples R China
来源：
JOURNAL OF DRUG TARGETING | 2024年 / 32卷 / 03期
关键词：
Survivin; cancer; IAP; apoptosis; mitosis; T cell development; ACUTE LYMPHOBLASTIC-LEUKEMIA; BREAST-CANCER; GASTRIC-CANCER; CELL-CYCLE; GENE-EXPRESSION; DOWN-REGULATION; DNA-DAMAGE; IN-VIVO; PHASE-I; ANTISENSE OLIGONUCLEOTIDES;
D O I：
10.1080/1061186X.2024.2309563
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP) family due to its predominant expression in tumours rather than normal terminally differentiated adult tissues. The high expression level of survivin in tumours is closely linked to chemotherapy resistance, heightened tumour recurrence, and increased tumour aggressiveness and serves as a negative prognostic factor for cancer patients. Consequently, survivin has emerged as a promising therapeutic target for cancer treatment. In this review, we delve into the various biological characteristics of survivin in cancers and its pivotal role in maintaining immune system homeostasis. Additionally, we explore different therapeutic strategies aimed at targeting survivin.
引用
收藏
页码：223 / 240
页数：18
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