Miller-Fisher Syndrome With Initial Manifestation of Rhinolalia Aperta: A Case Report and Literature Review

被引：0

作者：

Pacut, Peter ^{[1
]}

Han, Jee-Young ^{[1
]}

Ghasemi, Mehdi ^{[2
]}

机构：

[1] Univ Massachusetts, Chan Med Sch, Neurol, Worcester, MA 01655 USA

[2] Lahey Hosp & Med Ctr, Neurol, Burlington, MA 01805 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 10期

关键词：

intravenous immunoglobulin (ivig); anti-gq1b antibody; nasal speech; rhinolalia aperta; guillain-barre; syndrome (gbs); miller-fisher syndrome; GUILLAIN-BARRE-SYNDROME; OPHTHALMOPLEGIA; ANTIBODY; VARIANT; VOICE; IGG;

D O I：

10.7759/cureus.46376

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rhinolalia aperta (hypernasal speech) is rarely reported in patients with Miller-Fisher syndrome (MFS). Here, we report a patient with MFS who presented with rhinolalia aperta. A 35-year-old man with a history of alcohol abuse and hepatic cirrhosis presented with a three-day acute hypernasal voice change and numbness of both hands/thighs. After admission, the exam also revealed palatal hypomobility, decreased bilateral hand/thigh sensation, ataxic gait, dysmetria, areflexia, and bilateral abducens palsy. Serum immunoglobulin G (IgG) anti-GQ1b antibody titer was elevated (1:6400). A five-day intravenous IgG was administered with a robust clinical response. Oropharyngeal involvement in MFS can initially manifest with isolated hypernasal speech.

引用

页数：7

共 20 条

[1]

Abide Zakaria, 2023, Radiol Case Rep, V18, P2704, DOI 10.1016/j.radcr.2023.04.038

[2] SERUM ANTI-GQ(1B) IGG ANTIBODY IS ASSOCIATED WITH OPHTHALMOPLEGIA IN MILLER FISHER SYNDROME AND GUILLAIN-BARRE-SYNDROME - CLINICAL AND IMMUNOHISTOCHEMICAL STUDIES [J].

CHIBA, A ;

KUSUNOKI, S ;

OBATA, H ;

MACHINAMI, R ;

KANAZAWA, I .

NEUROLOGY, 1993, 43 (10) :1911-1917

[3] Guillain-Barre Syndrome and Variants [J].

Dimachkie, Mazen M. ;

Barohn, Richard J. .

NEUROLOGIC CLINICS, 2013, 31 (02) :491-+

[4] UNUSUAL VARIANT OF ACUTE IDIOPATHIC POLYNEURITIS (SYNDROME OF OPHTHALMOPLEGIA, ATAXIA AND AREFLEXIA) [J].

FISHER, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1956, 255 (02) :57-65

[5] Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria [J].

Fokke, Christiaan ;

van den Berg, Bianca ;

Drenthen, Judith ;

Walgaard, Christa ;

van Doorn, Pieter Antoon ;

Jacobs, Bart Casper .

BRAIN, 2014, 137 :33-43

[6] Miller Fisher Syndrome Presents as an Acute Voice Change to Hypernasal Speech [J].

Howell, Rebecca J. ;

Davolos, Alexandra G. ;

Clary, Matthew S. ;

Frake, Paul C. ;

Joshi, Arjun S. ;

Chaboki, Houtan .

LARYNGOSCOPE, 2010, 120 (05) :978-980

[7] Guillain-Barre syndrome [J].

Hughes, RAC ;

Cornblath, DR .

LANCET, 2005, 366 (9497) :1653-1666

[8] Anti-GT1 a IgG in Guillain-Barre syndrome [J].

Koga, M ;

Yoshino, H ;

Morimatsu, M ;

Yuki, N .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 72 (06) :767-771

[9]

Maryam D, 2021, World J Pharm Res., V7, P61

[10] Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barre syndrome in children: Report of two cases and review of the literature [J].

Michev, A. ;

Musso, P. ;

Foiadelli, T. ;

Trabatti, C. ;

Lozza, A. ;

Franciotta, D. ;

Simoncelli, A. M. ;

Savasta, S. .

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2019, 23 (01) :43-52

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