Synthesis of N-Unsubstituted and N3-Substituted Quinazoline-2,4(1H,3H)-diones from o-Aminobenzamides and CO2 at Atmospheric Pressure and Room Temperature

被引：0

作者：

Zhang, Lin ^{[1
,2
]}

Chen, Qian ^{[1
,2
]}

Li, Linlin ^{[1
,2
]}

Ma, Nana ^{[1
,2
]}

Tian, Jie ^{[1
,2
]}

Sun, Hao ^{[1
,2
]}

Xu, Qian ^{[1
,2
]}

Yang, Yuanyong ^{[1
,2
]}

Li, Chun ^{[1
,2
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Peoples R China

[2] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550004, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 14期

基金：

中国国家自然科学基金;

关键词：

CARBON-DIOXIDE; EFFICIENT SYNTHESIS; ISOCYANIDES; 2-AMINOBENZONITRILES; ALKALOIDS; CATALYSTS; ACCESS; AMINES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The unprecedented metal-free synthesis of both Nunsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones from o-aminobenzamides and CO2 under atmospheric pressure at room temperature is developed. This protocol easily allows for variations of functional groups (including alkyl, aryl, and heterocycle groups) at the N3-position to accommodate the construction of many important drugs and bioactive compounds. The reaction features eco-friendliness, substrate scope tolerance, and versatility and can be implemented even at the gram scale.

引用

页码：2471 / 2475

页数：5

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