Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes

被引:33
作者
Beals, Joseph W. [1 ]
Kayser, Brandon D. [1 ,2 ]
Smith, Gordon I. [1 ]
Schweitzer, George G. [1 ]
Kirbach, Kyleigh [1 ]
Kearney, Monica L. [1 ,3 ]
Yoshino, Jun [1 ,4 ]
Rahman, Gibraan [5 ,6 ]
Knight, Rob [5 ,6 ]
Patterson, Bruce W. [1 ]
Klein, Samuel [1 ,7 ]
机构
[1] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63130 USA
[2] Genentech Inc, South San Francisco, CA USA
[3] Southeast Missouri State Univ, Dept Kinesiol Nutr & Recreat, Cape Girardeau, MO USA
[4] Keio Univ, Sch Med, Dept Internal Med, Div Endocrinol Metab & Nephrol, Tokyo, Japan
[5] Univ Calif San Diego, Dept Pediat, San Diego, CA USA
[6] Univ Calif San Diego, Dept Comp Sci & Engn, San Diego, CA USA
[7] Sansum Diabet Res Inst, Santa Barbara, CA 93105 USA
基金
美国国家卫生研究院;
关键词
TYPE-2; DIABETES-MELLITUS; BETA-CELL FUNCTION; INSULIN SENSITIVITY; SKELETAL-MUSCLE; INTESTINAL MICROBIOTA; CALORIE RESTRICTION; PRACTICE GUIDELINES; INTENSITY EXERCISE; PHYSICAL-ACTIVITY; AMERICAN-COLLEGE;
D O I
10.1038/s42255-023-00829-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Beals, Kayser et al. demonstrate that exercise, in conjunction with diet-induced weight loss, causes greater improvement in whole-body insulin sensitivity than matched diet-induced weight loss alone in people with obesity and prediabetes. The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity (primary outcome) was 2-fold greater (P = 0.006) after 10% weight loss induced by calorie restriction plus exercise training (Diet+EX; n = 8, 6 women) than 10% weight loss induced by calorie restriction alone (Diet-ONLY; n = 8, 4 women) in participants in two concurrent studies. The greater improvement in insulin sensitivity was accompanied by increased muscle expression of genes involved in mitochondrial biogenesis, energy metabolism and angiogenesis (secondary outcomes) in the Diet+EX group. There were no differences between groups in plasma branched-chain amino acids or markers of inflammation, and both interventions caused similar changes in the gut microbiome. Few adverse events were reported. These results demonstrate that regular exercise during a diet-induced weight loss program has profound additional metabolic benefits in people with obesity and prediabetes.Trial Registration: ClinicalTrials.gov (NCT02706262 and NCT02706288)
引用
收藏
页码:1221 / +
页数:25
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