Protective mechanisms of intra- and extracellular polysaccharides from Schizophyllum commune on H2O2-induced oxidative damage of human skin fibroblasts

被引：8
|
作者：
Cheng, Wenjing [1 ,2 ,3 ]
Yang, Yundong [1 ,2 ,3 ]
Zhang, Jiachan [1 ,2 ,3 ,5 ]
Di, Fei qian [1 ,2 ,3 ]
Li, Luyao [1 ,2 ,3 ]
Wang, Changtao [1 ,2 ,3 ]
Li, Meng [1 ,2 ,3 ]
Zhao, Dan [1 ,2 ,3 ]
Shi, Xiuqin [4 ]
Huo, Tong [4 ]
An, Quan [4 ]
机构：
[1] Beijing Technol & Business Univ, Coll Chem & Mat Engn, Beijing, Peoples R China
[2] Beijing Technol & Business Univ, Beijing Key Lab Plant Resource Res & Dev, Beijing, Peoples R China
[3] Beijing Technol & Business Univ, Inst Cosmet Regulatory Sci, Beijing, Peoples R China
[4] Yunnan Baiyao Grp Co Ltd, Kunming 2203407, Peoples R China
[5] Beijing Technol & Business Univ, Coll Chem & Mat Engn, 11 Fucheng Rd,Haidian Dist, Beijing 100048, Peoples R China
来源：
FOOD AND AGRICULTURAL IMMUNOLOGY | 2023年 / 34卷 / 01期
关键词：
Schizophyllum commune; polysaccharide; anti-oxidation; Keap1-Nrf2; ARE signalling pathway; CHEMICAL-CHARACTERIZATION; ANTIOXIDATIVE ACTIVITIES; COLLAGEN HYDROLYSATE; FREE-RADICALS; STRESS; EXPRESSION; LUCIDUM; ACID; NRF2; RATS;
D O I：
10.1080/09540105.2023.2203407
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Schizophyllum commune is a fungus with applications both in medicine and foods, which produces IPS and EPS. However, there is no comparative study on the activity comparison of IPS and EPS and its mechanism of antioxidant effect. In this study, the antioxidant activities of the two polysaccharides were measured in biochemical, cellular and molecular levels, and H2O2 induced oxidative damage model of HSFs was established to explore the protective effects of EPS and IPS. We found IPS and EPS both achieved a good antioxidant effect. They can also improve the cellular levels of SOD and reduce MDA. Insights regarding the molecular mechanism were studied, we found that both EPS and IPS could increase the expression of Nrf2 in Keap1-Nrf2/ARE signaling pathway. At the same time, they could inhibit the expression of the negative feedback gene Keap1 and promote the expression of downstream gene GCLC, Gstt-1, Nqo1 and Ho-1.
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页数：18
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