Antimicrobial Activity of Sertraline on Listeria monocytogenes

被引：5
作者：
Wang, Yidi [1 ]
Li, Lili [2 ]
Cai, Pingyao [1 ]
Olsen, Rikke Heidemann [3 ]
Peng, Shuai [4 ,5 ]
Meng, Hecheng [1 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
[2] Jinan Univ, Inst Food Safety & Nutr, Guangzhou 510632, Peoples R China
[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Frederiksberg 1870, Denmark
[4] Wuhan Text Univ, Hubei Prov Engn Lab Clean Prod & High Value Utiliz, Wuhan 430073, Peoples R China
[5] South Cent Minzu Univ, Coll Life Sci, Wuhan 430074, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期
关键词：
Listeria monocytogenes; sertraline; antimicrobial activity; biofilm; virulence; BIOFILM FORMATION; VIRULENCE; ACID; STRAINS; GROWTH; GENES;
D O I：
10.3390/ijms24054678
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We explored the antimicrobial activity of sertraline on Listeria monocytogenes and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of L. monocytogenes. The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against L. monocytogenes were in the range of 16-32 mu g/mL and 64 mu g/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pH(in) in L. monocytogenes were observed. In addition, sertraline reduced the biofilm formation efficiency of the L. monocytogenes strains. Importantly, low concentrations (0.1 mu g/mL and 1 mu g/mL) of sertraline significantly down-regulated the expression levels of various L. monocytogens virulence genes (prfA, actA, degU, flaA, sigB, ltrC and sufS). These results collectively suggest a role of sertraline for the control of L. monocytogenes in the food industry.
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页数：12
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