H2O2/NIR-sensitive "two-step" nano theranostic system based hollow mesoporous copper sulfide/hyaluronic acid/JWH133 as an optimally designed delivery system for multidimensional treatment of RA

被引：10

作者：

Qiu, Shang ^{[1
,2
]}

Wu, Xiunan ^{[1
]}

Geng, Dechun ^{[3
]}

Pan, Wenzhen ^{[4
]}

Li, Zheng ^{[1
]}

Wang, Gang ^{[1
]}

Li, Daen ^{[1
]}

Li, Cheng ^{[2
]}

Feng, Shuo ^{[2
]}

Zhu, Liang ^{[2
]}

Xu, Yaozeng ^{[3
]}

Gao, Fenglei ^{[1
]}

机构：

[1] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221002, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Dept Orthoped, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China

[3] Soochow Univ, Dept Orthopaed, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

[4] Pingyin Peoples Hosp, Dept Orthoped, Jinan 250000, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 225卷

关键词：

RA; Cannabinoid receptors; Cannabinoid; Inflammation; Drug delivery; CANNABINOID RECEPTOR 2; FIBROBLAST-LIKE SYNOVIOCYTES; RHEUMATOID-ARTHRITIS; SYNOVIAL FIBROBLASTS; BONE; CB2; INFLAMMATION; EXPRESSION; CELL;

D O I：

10.1016/j.ijbiomac.2022.11.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cannabinoid receptors are widely distributed in many cells in Rheumatoid arthritis RA and strengthening factor to boost the development of RA diseases. Here, the hollow mesoporous copper sulfide (CuS) was used as the carrier skeleton and the cannabinoid type 2 (CB2) receptor agonist JWH133 was efficiently loaded inside of CuS through adsorption, then the outer layer was modified with hyaluronic acid (HA) to prevent the leakage of in-ternal drugs. After the CuS-JWH133@HA nano carrier reached the target area, HA responsive cracked under RA microenvironment to realize the first step of accurate drug delivery of JWH133, and the thermally responsive CuS under near-infrared (NIR) promoted the release of internal drugs. Then, JWH133 specifically combined CB2 receptors on the surface of macrophage, synovial cells and osteoblasts to realize the second step of drug delivery. The inflammatory factors secreted by cells are significantly inhibited, and the activity of osteoblasts was significantly enhanced. Therapeutic effect by CuS-JWH133@HA of RA was well verified by decreasing levels of inflammation in vivo and improvement of inflamed and swollen joints of mice. The CuS-JWH133@HA nano -composite showed satisfactory multidimensional therapeutic effect of RA in vitro and in vivo, which provided a novel idea for RA treatment.

引用

页码：298 / 309

页数：12