Photoresponsive polymeric microneedles: An innovative way to monitor and treat diseases

被引：13
作者：
Singh, Parbeen [1 ,2 ]
Youden, Brian [3 ,4 ]
Carrier, Andrew [3 ]
Oakes, Ken [5 ]
Servos, Mark [4 ]
Jiang, Runqing [6 ]
Lin, Sujing [2 ]
Nguyen, Thanh D. [1 ]
Zhang, Xu [3 ]
机构：
[1] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA
[2] Shenzhen Polytech, Sch Food & Drug, Shenzhen Key Lab Fermentat Purificat & Anal, Shenzhen 518055, Peoples R China
[3] Cape Breton Univ, Dept Chem, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
[4] Univ Waterloo, Dept Biol, 200 Univ Ave W, Waterloo, ON N2L 3G1, Canada
[5] Cape Breton Univ, Dept Biol, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
[6] Grand River Reg Canc Ctr, Dept Med Phys, Kitchener, ON N2G 1G3, Canada
来源：
JOURNAL OF CONTROLLED RELEASE | 2023年 / 353卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Phototherapies; Microneedles; Cancer therapy; Wound healing; Diabetes treatment; Diagnostics; TRIGGERED TRANSDERMAL DELIVERY; CHEMO-PHOTOTHERMAL THERAPY; DISSOLVING MICRONEEDLES; DRUG-DELIVERY; SEPARABLE MICRONEEDLES; NITRIC-OXIDE; PHOTODYNAMIC THERAPY; GLUCOSE-OXIDASE; LIGHT; RELEASE;
D O I：
10.1016/j.jconrel.2022.12.036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microneedles (MN) technology is an emerging technology for the transdermal delivery of therapeutics. When combined with photoresponsive (PR) materials, MNs can deliver therapeutics precisely and effectively with enhanced efficacy or synergistic effects. This review systematically summarizes the therapeutic applications of PRMNs in cancer therapy, wound healing, diabetes treatment, and diagnostics. Different PR approaches to activate and control the release of therapeutic agents from MNs are also discussed. Overall, PRMNs are a powerful tool for stimuli-responsive controlled-release therapeutic delivery to treat various diseases.
引用
收藏
页码：1050 / 1067
页数：18
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