Graphitic carbon nitride (g-C3N4)-based electrochemical sensors for the determination of antiviral

Acyclovir (ACR) is an antiviral drug used to treat chickenpox, shingles, and herpes infections in various parts of the body, including infants. It shortens illness duration and reduces symptoms, but may cause kidney damage and allergic reactions in some individuals. It may also be beneficial for those with compromised immune systems. ACR, despite its positive attributes, can cause kidney damage and allergic reactions in some individuals, requiring careful observation and monitoring. ACR was detected electrochemically in this work using graphitic carbon nitride (g-C3N4), which was effectively synthesized. Energy dispersive X-ray (EDX), X-ray diffraction (XRD), Raman, Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FESEM), and high-resolution transmission electron microscopy (HR-TEM) techniques were used to characterize the synthe-sized g-C3N4. To monitor ACR, g-C3N4 combined with pure carbon paste (g-C3N4/CPE) was used in voltammetric techniques. The sensor's ability to detect the ACR via g-C3N4 was investigated utilizing the amperometric i-t curve method. Electrochemical impedance spectroscopy (EIS) was used to examine the electrochemical characteristics of various electrodes. The Rct of the bare glassy carbon electrode (GCE), the bare CPE, and the g-C3N4/CPE were, respectively, 12770 omega, 3794 omega, and 3114 omega. From 10 mu M to 80 mu M ACR concentration, the current response rose linearly. The constructed sensor had an exceptional detection limit of 3.52 nM. By introducing 100 mu M concentrations of a variety of common interferents to the ACR solution during the measurement, it was possible to evaluate the impact of several foreign interferents on the outcomes at the g-C3N4. The electrochemical behavior of ACR was investigated in respect to several electrokinetic variables. The mechanism of potential electrochemical oxidation was demonstrated. The developed g-C3N4/CPE effectively identified ACR quantita-tively in samples of human blood serum and urine.