Research progress of glucocorticoid resistance in chronic rhinosinusitis with nasal polyps: A review

被引：2
作者：
Chen, Langlang [1 ,2 ]
Fan, Xin [1 ]
Yang, Lina [3 ]
Han, Lu [2 ]
Wang, Ningbo [1 ]
Bian, Ka [1 ,4 ]
机构：
[1] Air Force Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xian, Peoples R China
[2] Yanan Univ, Med Coll, Yanan, Peoples R China
[3] Air Fourth Med Univ, Sch Stomatol, State Key Lab Oral & Maxillofacial Reconstruct & R, Xian, Peoples R China
[4] Air Fourth Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xian 710000, Peoples R China
来源：
MEDICINE | 2023年 / 102卷 / 46期
关键词：
glucocorticoids; nasal polyps; receptors; resistance; rhinosinusitis; EOSINOPHILIC CHRONIC RHINOSINUSITIS; NF-KAPPA-B; ACUTE LYMPHOBLASTIC-LEUKEMIA; VITAMIN-D DECREASES; CORTICOSTEROID RESISTANCE; GASTROESOPHAGEAL-REFLUX; STEROID-RESISTANT; CHRONIC SINUSITIS; RECEPTOR-ALPHA; AIRWAY INFLAMMATION;
D O I：
10.1097/MD.0000000000036024
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the common chronic inflammatory diseases in otolaryngology. Glucocorticoid (GC) acts as the first-line drug for the treatment of CRSwNP in clinical practice, and they play an irreplaceable role in reducing nasal mucosal inflammation and restoring the normal physiological function of the nasal mucosa. However, many patients are still insensitive to GC treatment, known as GC resistance, which leads to poor control of the disease, and the underlying mechanisms are still not fully elucidated. This article provides a comprehensive overview of the research progress of GC resistance of patients with CRSwNP in recent years.
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