Amending the injured heart by in vivo reprogramming

被引：2

作者：

Yuan, Xuejun ^{[1
]}

Braun, Thomas ^{[1
,2
]}

机构：

[1] Max Planck Inst Heart & Lung Res, Dept Cardiac Dev & Remodeling, D-61231 Bad Nauheim, Germany

[2] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, Frankfurt, Germany

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2023年 / 82卷

关键词：

CARDIOMYOCYTE CELL-CYCLE; CARDIAC FIBROBLASTS; REGENERATION; DEDIFFERENTIATION; PROLIFERATION; MYOCYTES; TARGET; GROWTH; REPAIR; VITRO;

D O I：

10.1016/j.gde.2023.102098

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ischemic heart injury causes death of cardiomyocyte (CM), formation of a fibrotic scar, and often adverse cardiac remodeling, resulting in chronic heart failure. Therapeutic interventions have lowered myocardial damage and improved heart function, but pharmacological treatment of heart failure has only shown limited progress in recent years. Over the past two decades, different approaches have been pursued to regenerate the heart, by transplantation of newly generated CMs derived from pluripotent stem cells, generation of new CMs by reprogramming of cardiac fibroblasts, or by activating proliferation of preexisting CMs. Here, we summarize recent progress in the development of strategies for in situ generation of new CMs, review recent advances in understanding the underlying mechanisms, and discuss the challenges and future directions of the field.

引用

页数：8

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