The emerging roles of SUMOylation in pulmonary diseases

被引：5

作者：

Zheng, Xuyang ^{[1
]}

Wang, Lingqiao ^{[1
]}

Zhang, Zhen ^{[2
]}

Tang, Huifang ^{[3
]}

机构：

[1] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Pediat, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Orthoped Surg, Sch Med, Hangzhou 31000, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Basic Medicial Sci, Dept Pharmacol, Zhejiang Resp Drugs Res Lab, Hangzhou 310058, Zhejiang, Peoples R China

来源：

MOLECULAR MEDICINE | 2023年 / 29卷 / 01期

关键词：

SUMOylation; Pneumonia; cancer; Hypoxic pulmonary hypertension; Idiopathic pulmonary fibrosis; CELL LUNG-CANCER; C/EBP-ALPHA; TRANSCRIPTIONAL REGULATION; NUCLEOCAPSID PROTEIN; CONJUGATING ENZYME; TOPOISOMERASE-I; GENE-EXPRESSION; NUCLEAR EXPORT; ARGINASE; E3; LIGASE;

D O I：

10.1186/s10020-023-00719-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBP & alpha; in bronchopulmonary dysplasia (BDP), PPAR & gamma; in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health.

引用

页数：12

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