Synthesis of 1H-Isochromenes via Iridium-Catalyzed Cascade C-H Activation/Annulation of Pyridotriazoles at Room Temperature

被引：4

作者：

Lv, Guanghui ^{[1
,2
,3
,4
]}

Lin, Zheng ^{[1
,2
]}

Zhang, Cuimei ^{[1
,2
,3
]}

Xu, Shuran ^{[1
,2
,3
]}

Xu, Yanning ^{[1
,2
,3
]}

Li, Yuanyuan ^{[1
,2
,3
]}

Lai, Ruizhi ^{[1
,2
,3
]}

Nie, Ruifang ^{[5
]}

Yang, Zhongzhen ^{[1
,2
,3
]}

Wu, Yong ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Dept Med Chem, Sichuan Engn Lab Plant Sourced Drug, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China

[4] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan 442000, Hubei, Peoples R China

[5] Shandong First Med Univ, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China

来源：

ORGANOMETALLICS | 2023年 / 42卷 / 16期

关键词：

TRANSANNULATION REACTION; DENITROGENATIVE TRANSANNULATION; SULFOXONIUM YLIDES; EFFICIENT; ACID; ANHYDROEXFOLIAMYCIN; ISOCOUMARIN; METABOLITE; APOPTOSIS; ALKYNES;

D O I：

10.1021/acs.organomet.3c00224

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Anefficient iridium-catalyzed C-H activation/annulationreaction utilizing pyridotriazole as the traceless bifunctional directinggroup and carbene precursor to form 1H-isochromeneswas described. This reaction proceeded smoothly under an additive-freecondition at room temperature, which is compatible with a wide rangeof functional groups in high yields.

引用

页码：2228 / 2237

页数：10

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