Synthesis of 1H-Isochromenes via Iridium-Catalyzed Cascade C-H Activation/Annulation of Pyridotriazoles at Room Temperature

被引：4
作者：
Lv, Guanghui [1 ,2 ,3 ,4 ]
Lin, Zheng [1 ,2 ]
Zhang, Cuimei [1 ,2 ,3 ]
Xu, Shuran [1 ,2 ,3 ]
Xu, Yanning [1 ,2 ,3 ]
Li, Yuanyuan [1 ,2 ,3 ]
Lai, Ruizhi [1 ,2 ,3 ]
Nie, Ruifang [5 ]
Yang, Zhongzhen [1 ,2 ,3 ]
Wu, Yong [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Dept Med Chem, Sichuan Engn Lab Plant Sourced Drug, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China
[4] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan 442000, Hubei, Peoples R China
[5] Shandong First Med Univ, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China
来源：
ORGANOMETALLICS | 2023年 / 42卷 / 16期
关键词：
TRANSANNULATION REACTION; DENITROGENATIVE TRANSANNULATION; SULFOXONIUM YLIDES; EFFICIENT; ACID; ANHYDROEXFOLIAMYCIN; ISOCOUMARIN; METABOLITE; APOPTOSIS; ALKYNES;
D O I：
10.1021/acs.organomet.3c00224
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Anefficient iridium-catalyzed C-H activation/annulationreaction utilizing pyridotriazole as the traceless bifunctional directinggroup and carbene precursor to form 1H-isochromeneswas described. This reaction proceeded smoothly under an additive-freecondition at room temperature, which is compatible with a wide rangeof functional groups in high yields.
引用
收藏
页码：2228 / 2237
页数：10
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