Quantitative Edge Analysis of Pancreatic Margins in Patients with Chronic Pancreatitis: A Correlation with Exocrine Function

被引:4
作者
Ambrosetti, Maria Chiara [1 ]
Grecchi, Annamaria [2 ]
Ambrosetti, Alberto [3 ]
Amodio, Antonio [4 ]
Mansueto, Giancarlo [2 ]
Montemezzi, Stefania [1 ]
Zamboni, Giulia A. A. [2 ]
机构
[1] Azienda Osped Univ Integrata, Dept Pathol & Diagnost, Radiol Unit, I-37126 Verona, Italy
[2] Univ Verona, Inst Radiol, Dept Diagnost & Publ Hlth, Policlin GB Rossi, I-37134 Verona, Italy
[3] Univ Padua, Dept Phys & Astron Galileo Galilei, I-35131 Padua, Italy
[4] GB Rossi Univ Hosp, Pancreas Inst, Dept Med, Gastroenterol & Digest Endoscopy Unit, I-37134 Verona, Italy
关键词
chronic pancreatitis; multidetector computed tomography; computer-assisted diagnosis; PANCREATOGRAPHY; GUIDELINES; DIAGNOSIS;
D O I
10.3390/diagnostics13132272
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Many efforts have been made to improve accuracy and sensitivity in diagnosing chronic pancreatitis (CP), obtaining quantitative assessments related to functional data. Our purpose was to correlate a computer-assisted analysis of pancreatic morphology, focusing on glandular margins, with exocrine function-measured by fecal elastase values-in chronic pancreatitis patients. Methods: We retrospectively reviewed chronic pancreatitis patients who underwent fecal elastase assessment and abdominal MRI in our institute within 1 year. We identified 123 patients divided into three groups based on the fecal elastase value: group A with fecal elastase > 200 & mu;g/g; group B with fecal elastase between 100 and 200 & mu;g/g; and group C with fecal elastase < 100 & mu;g/g. Computer-assisted quantitative edge analysis of pancreatic margins was made on non-contrast-enhanced water-only Dixon T1-weighted images, obtaining the pancreatic margin score (PMS). PMS values were compared across groups using a Kruskal-Wallis test and the correlation between PMS and fecal elastase values was tested with the Spearman's test. Results: A significant difference in PMS was observed between the three groups (p < 0.0001), with a significant correlation between PMS and elastase values (r = 0.6080). Conclusions: Quantitative edge analysis may stratify chronic pancreatitis patients according to the degree of exocrine insufficiency, potentially contributing to the morphological and functional staging of this pathology.
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页数:12
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