Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

被引：91
作者：
Wood, Stephen J. [1 ,2 ]
Kuzel, Timothy M. [1 ,3 ]
Shafikhani, Sasha H. [1 ,2 ,3 ]
机构：
[1] Rush Univ, Dept Med, Div Hematol Oncol & Cell Therapy, Med Ctr, Chicago, IL 60612 USA
[2] Rush Univ, Dept Microbial Pathogens & Immun, Med Ctr, Chicago, IL 60612 USA
[3] Rush Univ, Canc Ctr, Med Ctr, Chicago, IL 60612 USA
来源：
CELLS | 2023年 / 12卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Pseudomonas aeruginosa; infection; acute infections; chronic infections; cystic fibrosis (CF); antibiotic resistance; virulence factors; animal modeling; VENTILATOR-ASSOCIATED PNEUMONIA; HYPERBARIC-OXYGEN THERAPY; BLOOD-STREAM INFECTIONS; EXTENSIVELY DRUG-RESISTANT; SURGICAL SITE INFECTION; HOSPITAL-ACQUIRED PNEUMONIA; GRAM-NEGATIVE BACTERIA; INTENSIVE-CARE-UNIT; SIDEROPHORE CEPHALOSPORIN CEFIDEROCOL; URINARY-TRACT-INFECTION;
D O I：
10.3390/cells12010199
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes P. aeruginosa a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. In this review, we review the important acute and chronic infections caused by this pathogen. We next discuss various animal models which have been developed to evaluate P. aeruginosa pathogenesis and assess therapeutics against this pathogen. Next, we review current treatments (antibiotics and vaccines) and provide an overview of their efficacies and their limitations. Finally, we highlight exciting literature on novel antibiotic-free strategies to control P. aeruginosa infections.
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页数：37
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