The escalating demand for aggregates in the construction sector has significantly strained the preservation of mountains and ecosystems. This study explores the use of toughened glass waste (TGW) aggregates as an architectural and construction material by assessing the strength, and microstructural properties of highperformance concrete (HPC). Statistical relationships were established and validated to model the mechanical characteristics of HPC using various parameters derived from collected data. Furthermore, Toughened glass waste was incorporated in HPC as 25%, 50%, 75%, and 100% replacement of coarse aggregate. Mechanical properties were studied, until 90 days, using standard curing conditions (20 C-degrees). Results show that regression models were found to be significant, providing reliable predictions with high R-2 values and favorable p -values (0.0001). An increase in strength was observed in HPC with a 50% replacement of TGW aggregates. In addition, the flexural strength of HPC was significantly enhanced with the increase in TGW aggregates ratio. Microstructural characterization was conducted using field emission scanning electron microscopy (FESEM), and x-ray diffraction analysis (XRD) revealing the formation of dense Calcium -silicate -hydrate (CSH) gel and stratlingite (CASH) in the blended HPC mixes. Based on these findings, the TGW-HPC was determined to be adequate for construction infrastructure applications.