A review focusing on the role of pyroptosis in prostate cancer

被引:4
作者
Liu, Zhewen [1 ,2 ]
Kuang, Shida [1 ]
Chen, Qihua [1 ,2 ]
机构
[1] Hunan Univ Chinese Med, Changsha, Peoples R China
[2] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410007, Peoples R China
关键词
gasdermin; prediction; prostate cancer; pyroptosis; treatment; ANDROGEN DEPRIVATION THERAPY; QUALITY-OF-LIFE; NLRP3; INFLAMMASOME; NONCODING RNAS; PORE FORMATION; GASDERMIN D; CELL-DEATH; MECHANISM; GSDMD; CASPASE-11;
D O I
10.1097/MD.0000000000036605
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
As one of the types of programmed cell death, pyroptosis has become a focus of research in recent years. Numerous studies have shown that pyroptosis plays a regulatory role in tumor cell invasiveness, differentiation, proliferation, and metastasis. It has been demonstrated that pyroptosis is involved in the regulation of signaling pathways implicated in the pathogenesis of prostate cancer (PCa). Furthermore, the loss of expression of pyroptosis-related genes in PCa has been reported, and pyroptosis-related genes have demonstrated a considerable ability in predicting the prognosis of PCa. Therefore, the potential role of pyroptosis in regulating the development of PCa warrants further investigation and attention. In this review, we summarize the basics of the role of pyroptosis and also discuss research into the mechanisms of action associated with pyroptosis in PCa. It is hoped that by exploring the potential of the pyroptosis pathway in intervening in PCa, it will provide a viable direction for the diversification of PCa treatment.
引用
收藏
页数:9
相关论文
共 107 条
[1]  
Abbafati C, 2020, LANCET, V396, P1204
[2]   Targeting noncoding RNAs in disease [J].
Adams, Brian D. ;
Parsons, Christine ;
Walker, Lisa ;
Zhang, Wen Cai ;
Slack, Frank J. .
JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (03) :761-771
[3]   GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].
Aglietti, Robin A. ;
Estevez, Alberto ;
Gupta, Aaron ;
Ramirez, Monica Gonzalez ;
Liu, Peter S. ;
Kayagaki, Nobuhiko ;
Ciferri, Claudio ;
Dixit, Vishva M. ;
Dueber, Erin C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863
[4]   NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5 [J].
Baker, Paul J. ;
Boucher, Dave ;
Bierschenk, Damien ;
Tebartz, Christina ;
Whitney, Paul G. ;
D'Silva, Damian B. ;
Tanzer, Maria C. ;
Monteleone, Mercedes ;
Robertson, Avril A. B. ;
Cooper, Matthew A. ;
Alvarez-Diaz, Silvia ;
Herold, Marco J. ;
Bedoui, Sammy ;
Schroder, Kate ;
Masters, Seth L. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (10) :2918-2926
[5]  
Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[6]   Salmonella induces macrophage death by caspase-1-dependent necrosis [J].
Brennan, MA ;
Cookson, BT .
MOLECULAR MICROBIOLOGY, 2000, 38 (01) :31-40
[7]   The gasdermins, a protein family executing cell death and inflammation [J].
Broz, Petr ;
Pelegrin, Pablo ;
Shao, Feng .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (03) :143-157
[8]   Inflammasomes: mechanism of assembly, regulation and signalling [J].
Broz, Petr ;
Dixit, Vishva M. .
NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420
[9]   Mechanisms of Multidrug Resistance in Cancer Chemotherapy [J].
Bukowski, Karol ;
Kciuk, Mateusz ;
Kontek, Renata .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (09)
[10]   The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones [J].
Cech, Thomas R. ;
Steitz, Joan A. .
CELL, 2014, 157 (01) :77-94