Shedding light on latent pathogenesis and pathophysiology of mental disorders: the potential of iPS cell technology

被引：4

作者：

Arioka, Yuko ^{[1
,2
]}

Okumura, Hiroki ^{[1
,3
]}

Sakaguchi, Hideya ^{[4
]}

Ozaki, Norio ^{[1
,5
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Pathophysiol Mental Disorders, Nagoya, Japan

[2] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Nagoya, Japan

[3] Nagoya Univ Hosp, Hosp Pharm, Nagoya, Japan

[4] RIKEN, Ctr Biosyst Dynam Res, BDR Otsuka Pharmaceut Collaborat Ctr, Kobe, Japan

[5] Nagoya Univ, Inst Glycocore Res iGCORE, Nagoya, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2023年 / 77卷 / 06期

关键词：

disease modeling; genetic variant; iPS cell; mental disorders; neural organoid; HUMAN BRAIN-DEVELOPMENT; PLURIPOTENT STEM-CELLS; CEREBRAL ORGANOIDS; SELF-ORGANIZATION; MODEL; NEURONS; DIFFERENTIATION; SCHIZOPHRENIA; GENERATION; CULTURE;

D O I：

10.1111/pcn.13545

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mental disorders are considered as one of the major healthcare issues worldwide owing to their significant impact on the quality of life of patients, causing serious social burdens. However, it is hard to examine the living brain-a source of psychiatric symptoms-at the cellular, subcellular, and molecular levels, which poses difficulty in determining the pathogenesis and pathophysiology of mental disorders. Recently, induced pluripotent stem cell (iPSC) technology has been used as a novel tool for research on mental disorders. We believe that the iPSC-based studies will address the limitations of other research approaches, such as human genome, postmortem brain study, brain imaging, and animal model analysis. Notably, studies using integrated iPSC technology with genetic information have provided significant novel findings to date. This review aimed to discuss the history, current trends, potential, and future of iPSC technology in the field of mental disorders. Although iPSC technology has several limitations, this technology can be used in combination with the other approaches to facilitate studies on mental disorders.

引用

页码：308 / 314

页数：7

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