Preconceptional exposure of adult male rats to bisphenol S impairs insulin sensitivity and glucose tolerance in their male offspring

被引:5
作者
Gong, Pengfei [1 ,4 ]
Bailbe, Danielle [1 ]
Tolu, Stefania [1 ]
Pommier, Gaelle [1 ,2 ]
Liu, Junjun [3 ]
Movassat, Jamileh [1 ]
机构
[1] Univ Paris Cite, CNRS, Unite Biol Fonctionnelle & Adaptat, F-75013 Paris, France
[2] Univ Paris Cite, UFR Sci Vivant, F-75013 Paris, France
[3] Shandong First Med Univ, Shandong Inst Endocrine & Metab Dis, Jinan, Shandong, Peoples R China
[4] Shandong First Med Univ, Coll Artificial Intelligence & Big Data Med Sci, Jinan, Shandong, Peoples R China
关键词
Paternal programming; Bisphenol S; Insulin sensitivity; Glucose tolerance; Insulin secretion; HIGH-FAT DIET; BPA EXPOSURE; A EXPOSURE; PERINATAL EXPOSURE; SPERM; INHERITANCE; SPERMATOZOA; HOMEOSTASIS; INTOLERANCE; EXPRESSION;
D O I
10.1016/j.chemosphere.2022.137691
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Since the use of bisphenol A (BPA) has been restricted because of its endocrine disruptor properties, bisphenol S (BPS) has been widely used as a substitute of BPA. However, BPS exerts similar effects on metabolic health as BPA. The effects of maternal exposure to BPA and BPS on the metabolic health of offspring have been largely documented during the past decade. However, the impact of preconceptional paternal exposure to BPS on progenies remains unexplored. In this study we investigated the impact of paternal exposure to BPS before conception, on the metabolic phenotype of offspring. Male Wistar rats were administered BPS through drinking water at the dose of 4 mu g/kg/day (BPS-4 sires) or 40 mu g/kg/day (BPS-40 sires) for 2 months before mating with females. The progenies (F1) were studied at fetal stage and in adulthood. We showed that preconceptional paternal exposure to BPS for 2 months did not alter the metabolic status of sires. The female offspring of sires exposed to lower or higher doses of BPS showed no alteration of their metabolic phenotype compared to females from control sires. In contrast, male offspring of BPS-4 sires exhibited increased body weight and body fat/lean ratio, decreased insulin sensitivity and increased glucose-induced insulin secretion at adult age, compared to the male offspring of control sires. Moreover, male offspring of BPS-4 sires developed glucose intolerance later in life. None of these effects were apparent in male offspring of BPS-40 sires. In conclusion, our study provides the first evidence of the non-monotonic and sex-specific effects of preconceptional paternal exposure to BPS on the metabolic health of offspring, suggesting that BPS is not a safe BPA substitute regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
引用
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页数:12
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