Aqueous electrolyte-gated solution-processed metal oxide transistors for direct cellular interfaces

被引：10

作者：

Kang, Dong-Hee ^{[1
]}

Choi, Jun-Gyu ^{[1
]}

Lee, Won-June ^{[1
]}

Heo, Dongmi ^{[1
]}

Wang, Sungrok ^{[1
]}

Park, Sungjun ^{[2
]}

Yoon, Myung-Han ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Sch Mat Sci & Engn, Gwangju 61005, South Korea

[2] Ajou Univ, Elect & Comp Engn, Suwon 16499, South Korea

来源：

APL BIOENGINEERING | 2023年 / 7卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

THIN-FILM TRANSISTORS; ACTION-POTENTIALS; PHOTOCHEMICAL ACTIVATION; STIMULATION; ARRAYS; PERFORMANCE; ELECTRONICS; BIOSENSOR; TRANSIENT; NEURONS;

D O I：

10.1063/5.0138861

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrolyte-gated thin-film transistor made of large-area solution-processed indium-gallium-zinc oxide (IGZO) semiconductors capable of directly interacting with live cells at physiological conditions. The fabricated transistors exhibit good electrical performance operating under sub-0.5 V conditions with high on-/off-current ratios (>10(7)) and transconductance (>1.0 mS) over an extended operational lifetime. Furthermore, we verified the biocompatibility of the IGZO surface to various types of mammalian cells in terms of cell viability, proliferation, morphology, and drug responsiveness. Finally, the prolonged stable operation of electrolyte-gated transistor devices directly integrated with live cells provides the proof-of-concept for solution-processed metal oxide material-based direct cellular interfaces.

引用

页数：9

共 54 条

[1] Printed microelectrode arrays on soft materials: from PDMS to hydrogels [J].

Adly, Nouran ;

Weidlich, Sabrina ;

Seyock, Silke ;

Brings, Fabian ;

Yakushenko, Alexey ;

Offenhaeusser, Andreas ;

Wolfrum, Bernhard .

NPJ FLEXIBLE ELECTRONICS, 2018, 2 (01)

[2] Electron transporting water-gated thin film transistors [J].

Al Naim, Abdullah ;

Grell, Martin .

APPLIED PHYSICS LETTERS, 2012, 101 (14)

[3] Impact of layer thickness on the operating characteristics of In2O3/ZnO heterojunction thin-film transistors [J].

AlGhamdi, Wejdan S. ;

Fakieh, Aiman ;

Faber, Hendrik ;

Lin, Yen-Hung ;

Lin, Wei-Zhi ;

Lu, Po-Yu ;

Liu, Chien-Hao ;

Salama, Khaled Nabil ;

Anthopoulos, Thomas D. .

APPLIED PHYSICS LETTERS, 2022, 121 (23)

[4] Low-temperature, high-performance solution-processed metal oxide thin-film transistors formed by a 'sol-gel on chip' process [J].

Banger, K. K. ;

Yamashita, Y. ;

Mori, K. ;

Peterson, R. L. ;

Leedham, T. ;

Rickard, J. ;

Sirringhaus, H. .

NATURE MATERIALS, 2011, 10 (01) :45-50

[5]

Benfenati V, 2013, NAT MATER, V12, P672, DOI [10.1038/NMAT3630, 10.1038/nmat3630]

[6] Low-temperature crystallization of indium oxide thin films with a photoactivable additive [J].

Choi, Jun-Gyu ;

Lee, Won-June ;

Jo, Yong-Ryun ;

Na, Hyeonjun ;

Lee, Sangwoo ;

Kim, Bong-Joong ;

Yoon, Myung-Han .

APPLIED PHYSICS LETTERS, 2022, 121 (24)

[7] Organic ultra-thin film transistors with a liquid gate for extracellular stimulation and recording of electric activity of stem cell-derived neuronal networks [J].

Cramer, Tobias ;

Chelli, Beatrice ;

Murgia, Mauro ;

Barbalinardo, Marianna ;

Bystrenova, Eva ;

de Leeuw, Dago M. ;

Biscarini, Fabio .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2013, 15 (11) :3897-3905

[8] Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation [J].

Cuttaz, Estelle A. ;

Chapman, Christopher A. R. ;

Syed, Omaer ;

Goding, Josef A. ;

Green, Rylie A. .

ADVANCED SCIENCE, 2021, 8 (08)

[9] Transient, Biocompatible Electronics and Energy Harvesters Based on ZnO [J].

Dagdeviren, Canan ;

Hwang, Suk-Won ;

Su, Yewang ;

Kim, Stanley ;

Cheng, Huanyu ;

Gur, Onur ;

Haney, Ryan ;

Omenetto, Fiorenzo G. ;

Huang, Yonggang ;

Rogers, John A. .

SMALL, 2013, 9 (20) :3398-3404

[10] Diamond Transistor Array for Extracellular Recording From Electrogenic Cells [J].

Dankerl, Markus ;

Eick, Stefan ;

Hofmann, Boris ;

Hauf, Moritz ;

Ingebrandt, Sven ;

Offenhaeusser, Andreas ;

Stutzmann, Martin ;

Garrido, Jose A. .

ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (18) :2915-2923

← 1 2 3 4 5 6 →