Trimethylamine N-Oxide levels increase in patients with severe and non-severe COVID-19

被引：0

作者：

Yasak, Ibrahim Halil ^{[1
,6
]}

Yilmaz, Mustafa ^{[2
]}

Ceylan, Mehmet Resat ^{[3
]}

Koyuncu, Ismail ^{[4
]}

Seyhanli, Eyyup Sabri ^{[5
]}

机构：

[1] Harran Univ, Fac Med, Dept Emergency Med, Sanliurfa, Turkiye

[2] Firat Univ, Fac Med, Dept Emergency Med, Elazig, Turkiye

[3] Harran Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Fac Med, Sanliurfa, Turkiye

[4] Harran Univ, Fac Med, Dept Med Biochem, Sanliurfa, Turkiye

[5] Hlth Sci Univ, Mehmet Akif Inan Res & Training Hosp, Emergency Dept, Sanliurfa, Turkiye

[6] Harran Univ, Fac Med, Dept Emergency Med, TR-63300 Sanliurfa, Turkiye

来源：

ANNALS OF CLINICAL AND ANALYTICAL MEDICINE | 2023年 / 14卷 / 01期

关键词：

Biomarkers; COVID-19; Peripheral Blood; Severe; Trimethylamine N-oxide; TMAO; CHOLINE; RISK;

D O I：

10.4328/ACAM.21403

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: This study aimed to measure and evaluate serum trimethylamine N-oxide (TMAO) levels in patients with COVID-19. Material and Methods: The patients were divided into three groups according to their polymerase chain reaction (PCR) results and the clinical picture of the disease: Group 1 (negative PCR result, n = 44), Group 2 (positive PCR result and non-severe disease, n = 38) and Group 3 (positive PCR result and severe disease, n = 45).Results: TMAO levels were significantly different among the three patient groups. Post Hoc Dunn's analysis revealed a significant difference between Group 1 and Group 2 (p = 0.006), Group 1 and Group 3 (p < 0.001) and Group 2 and Group 3 (p = 0.031). ROC analysis revealed that a cut-off value of 2.92 had a sensitivity of 74.70%, a specificity of 68.18%, a positive predictive value of 81.6% and a negative predictive value of 58.8%.Discussion: The results of this study demonstrated that TMAO levels increased in the patients with COVID-19, and further TMAO levels increased as the severity of the disease progressed.

引用

页码：30 / 34

页数：5

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