Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals

被引：34

作者：

Brum, Wagner S. ^{[1
,2
]}

Ashton, Nicholas J. ^{[1
,3
,4
,5
,6
]}

Simren, Joel ^{[1
]}

di Molfetta, Guiglielmo ^{[1
]}

Karikari, Thomas K. ^{[1
,7
]}

Benedet, Andrea L. ^{[1
]}

Zimmer, Eduardo R. ^{[2
,8
,9
,10
]}

Lantero-Rodriguez, Juan ^{[1
]}

Montoliu-Gaya, Laia ^{[1
]}

Jeromin, Andreas ^{[11
]}

Aarsand, Aasne K. ^{[12
,13
]}

Bartlett, William A. ^{[12
,14
]}

Calle, Pilar Fernandez ^{[12
,15
]}

Coskun, Abdurrahman ^{[12
,16
]}

Diaz-Garzon, Jorge ^{[12
,15
]}

Jonker, Niels ^{[12
,17
]}

Zetterberg, Henrik ^{[1
,6
,18
,19
,20
,21
]}

Sandberg, Sverre ^{[12
,13
,22
]}

Carobene, Anna ^{[12
,23
]}

Blennow, Kaj ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Psychiat & Neurochem, Sahlgrenska Acad, Inst Neurosci & Physiol, Molndal, Sweden

[2] Univ Fed Rio Grande Sul UFRGS, Dept Biochem, Porto Alegre, RS, Brazil

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Inst Clin Neurosci Inst, London, England

[4] South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth & Biomed Res Unit, London, England

[5] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[6] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[7] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[8] Univ Fed Rio Grande Sul UFRGS, Dept Pharmacol, Porto Alegre, RS, Brazil

[9] Univ Fed Rio Grande Sul UFRGS, Grad Program Biol Sci, Porto Alegre, RS, Brazil

[10] McGill Univ, McGill Ctr Studies Aging, Verdun, PQ, Canada

[11] ALZpath Inc, Carlsbad, CA USA

[12] European Federat Clin Chem & Lab Med Working Grp, Milan, Italy

[13] Haraldsplass Deaconess Hosp, Norwegian Org Qual Improvement Lab Examinat NOKLU, Bergen, Norway

[14] Univ Dundee, Sch Sci & Engn, Dundee, Scotland

[15] La Paz Univ Hosp, Dept Lab Med, Madrid, Spain

[16] Acibadem Mehmet Ali Aydinlar Univ, Dept Med Biochem, Sch Med, Istanbul, Turkiye

[17] Wilhelmina Ziekenhuis Assen, Certe, Assen, Netherlands

[18] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[19] UCL, UK Dementia Res Inst, London, England

[20] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

[21] Univ Wisconsin Madison, Sch Med & Publ Hlth, Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA

[22] Univ Bergen, Dept Global Hlth & Primary Care, Fac Med, Bergen, Norway

[23] IRCCS San Raffaele Sci Inst, Lab Med, Milan, Italy

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 02期

基金：

瑞典研究理事会;

关键词：

amyloid; analytical variation; biological variation; glial fibrillary acidic protein; neurofilament light; plasma biomarkers; phosphorylated tau; reference change values; ANALYTICAL PERFORMANCE SPECIFICATIONS; PERSONALIZED REFERENCE INTERVALS; CLINICAL-CHEMISTRY; DIFFERENT DISTRIBUTIONS; EUROPEAN FEDERATION; CRITICAL-APPRAISAL; WORKING GROUP; AMYLOID-BETA; EUBIVAS; CHECKLIST;

D O I：

10.1002/alz.13518

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Blood biomarkers have proven useful in Alzheimer's disease (AD) research. However, little is known about their biological variation (BV), which improves the interpretation of individual-level data. METHODS: We measured plasma amyloid beta (A ss 42, A ss 40), phosphorylated tau (ptau181, p-tau217, p-tau231), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) in plasma samples collected weekly over 10 weeks from 20 participants aged 40 to 60 years from the European Biological Variation Study. We estimated within- (CVI) and between-subject (CVG) BV, analytical variation, and reference change values (RCV). RESULTS: Biomarkers presented considerable variability in CVI and CVG. A ss 42/A ss 40 had the lowest CVI (approximate to 3%) and p-tau181 the highest (approximate to 16%), while others ranged from 6% to 10%. Most RCVs ranged from 20% to 30% (decrease) and 25% to 40% (increase). DISCUSSION: BV estimates for AD plasma biomarkers can potentially refine their clinical and research interpretation. RCVs might be useful for detecting significant changes between serial measurements when monitoring early disease progression or interventions.

引用

页码：1284 / 1297

页数：14

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