Ferroptosis of immune cells in the tumor microenvironment

Ferroptosis is a distinct form of cell death driven by the accumulation of peroxidized lipids. Characterized by alterations in redox lipid metabolism, ferrop-tosis has been implicated in a variety of cellular processes, including cancer. In-duction of ferroptosis is considered a novel way to kill tumor cells, especially cells resistant to radiation and chemotherapy. However, in recent years, a new paradigm has emerged. In addition to promoting tumor cell death, ferroptosis causes potent immune suppression in the tumor microenvironment (TME) by af-fecting both innate and adaptive immune responses. In this review, we discuss the dual role of ferroptosis in the antitumor and protumorigenic functions of im-mune cells in cancer. We suggest strategies for targeting ferroptosis, taking into account its ambiguous role in cancer.