Should multidrug resistant Klebsiella pneumoniae strains displaying hypervirulent traits be reclassified as either ultravirulent or supervirulent?

被引:13
作者
Douradinha, Bruno [1 ]
机构
[1] Nykode Therapeut ASA, Oslo Sci Pk,Gaustadalleen 21, N-0349 Oslo, Norway
关键词
Klebsiella pneumoniae; Virulence; Hypervirulence; Ultravirulence; Nocosomial infections; Antimicrobial resistance;
D O I
10.1016/j.micres.2023.127446
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Historically, Klebsiella pneumoniae isolates were described either as hypervirulent or classical. While hypervirulent strains display a precise phenotype (thicker capsule, hypermucoviscosity, absence of antibiotic resistance markers, several siderophores, etc.), classical strains can relate to all other K. pneumoniae strains, including virulent multidrug-resistant clinical isolates. Recently, many surveillance studies reported virulent K. pneumoniae nosocomial strains resistant to all antibiotic classes which also contain genetic markers associated with hypervirulence. Due to their higher virulence and clinical importance, here it is proposed reclassify them as ultravirulent and as supervirulent, to distinguish them from each other and from those with either hypervirulent or virulent phenotypes.
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收藏
页数:5
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