Head-to-Head Comparison Between Rabbit Sign and EANM/SNMMI Criteria for the 18F-DOPA Visual Assessment of Parkinsonian Syndromes in PET/MRI A Multiple Expert-Based and Blinded Controlled Study

被引：1

作者：

Goldfarb, Lucas ^{[1
]}

Iep, Alex ^{[1
]}

Chawki, Mohammad Bilal ^{[1
]}

Nguyen, Loc ^{[1
]}

Lun, Francois ^{[2
]}

Carpentier, Amer-Adam Al Najjar ^{[3
]}

de Recondo, Anne

Blin, Jerome ^{[4
]}

Bourdinaud, Valerie ^{[5
]}

Morin, Ludovic ^{[6
]}

Andriatsiferana, Harisoa ^{[7
]}

Ferreira, Andre ^{[8
]}

Deschiens, Anne Marie

Brulon, Vincent ^{[1
]}

Comtat, Claude ^{[1
]}

Lebon, Vincent ^{[1
,9
]}

Besson, Florent L. ^{[1
,10
]}

机构：

[1] CEA, Serv Hosp Freder Joliot, Orsay, France

[2] Grp Hosp Nord Essonne, Serv Neurol, Longjumeau, France

[3] Grp Hosp Nord Essonne, Ctr Cerveau Moelle & Nerf, Longjumeau, France

[4] Clin Memoire, Paris, France

[5] Hop Pr Geriatr Magnolias, Ballainvilliers, France

[6] Grp Hosp Sainte Anne, Serv Neurol, Paris, ON, Canada

[7] CH Arpajon, Arpajon, France

[8] Hop Prive Antony, Serv Neurol, Antony, France

[9] Univ Paris Saclay, Inserm, CNRS, CEA,BioMaps, Orsay, France

[10] CEA, Serv Hosp Freder Joliot, 4 Pl Gen Leclerc, F-91400 Orsay, France

来源：

CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 02期

关键词：

PET; MRI; F-18-DOPA; parkinsonian syndromes; visual analysis; FP-CIT SPECT; DOPAMINERGIC SYSTEM; DAT-SPECT; DOPA PET; DIAGNOSIS; DISEASE;

D O I：

10.1097/RLU.0000000000004481

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PurposeThe aim of this study was to compare the diagnostic performance of the rabbit visual pattern versus the one endorsed by the EANM/SNMMI for the diagnosis of parkinsonian syndromes in PET/MRI.Patients and MethodsThe F-18-DOPA PET images of 129 consecutive patients (65 Park+ and 64 controls) with 1 year of clinical follow-up were reviewed independently by 5 experienced readers on the same imaging workstation, blinded to the final clinical diagnosis. Two visual methods were assessed independently, with several days to months of interval: the criteria endorsed by EANM/SNMMI and the "rabbit" shape of the striate assessed on 3D MIP images. The sensitivities, specificities, likelihood ratios, and predictive values of the 2 diagnostic tests were estimated simultaneously by using the "comparison of 2 binary diagnostic tests to a paired design" method.ResultsThe estimated 95% confidence interval (CI) of sensitivities and specificities ranged from 49.4% to 76.5% and from 83.2% to 97.7%, respectively. The 95% CI estimates of positive and negative likelihood ratios ranged from 3.8 to 26.7 and from 0.26 to 0.56, respectively. The 95% CI estimates of the positive and negative predictive values ranged from 78.1% to 96.7% and from 60.3% to 81.4%, respectively. For all the parameters, no statistical difference was observed between the 2 methods (P > 0.05). The rabbit sign reduced the readers' discrepancies by 25%, while maintaining the same performance.ConclusionsThe rabbit visual pattern appears at least comparable to the current EANM/SNMMI reference procedure for the assessment of parkinsonian syndromes in daily clinical practice, without the need of any image postprocessing. Further multicenter prospective studies would be of relevance to validate these findings.

引用

页码：112 / 118

页数：7