SGLT2 Inhibitors in Aging-Related Cardiovascular Disease: A Review of Potential Mechanisms

被引：5
作者：
Zhang, Yali [1 ,2 ]
He, Yufeng [1 ,2 ]
Liu, Siqi [1 ,2 ]
Deng, Li [3 ]
Zuo, Yumei [1 ,2 ]
Huang, Keming [1 ,2 ]
Liao, Bin [4 ]
Li, Guang [1 ,2 ]
Feng, Jian [1 ,2 ]
机构：
[1] Southwest Med Univ, Affiliated Hosp, Dept Cardiol, Key Lab Med Electrophysiol,Minist Educ, Luzhou, Peoples R China
[2] Southwest Med Univ, Inst Cardiovasc Res, Med Electrophysiol Key Lab Sichuan Prov, Luzhou, Peoples R China
[3] Southwest Med Univ, Affiliated Hosp, Dept Rheumatol, Luzhou, Sichuan, Peoples R China
[4] Southwest Med Univ, Affiliated Hosp, Dept Cardiac Surg, Luzhou, Peoples R China
来源：
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS | 2023年 / 23卷 / 06期
关键词：
VASCULAR ENDOTHELIAL DYSFUNCTION; NF-KAPPA-B; COTRANSPORTER; INHIBITOR; OXIDATIVE STRESS; NITRIC-OXIDE; MITOCHONDRIAL-DNA; BLOOD-PRESSURE; HEART-FAILURE; INSULIN-RESISTANCE; MACROPHAGE POLARIZATION;
D O I：
10.1007/s40256-023-00602-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Population aging combined with higher susceptibility to cardiovascular diseases in older adults is increasing the incidence of conditions such as atherosclerosis, myocardial infarction, heart failure, myocardial hypertrophy, myocardial fibrosis, arrhythmia, and hypertension. sodium-glucose cotransporter 2 inhibitors (SGLT2i) were originally developed as a novel oral drug for patients with type 2 diabetes mellitus. Unexpectedly, recent studies have shown that, beyond their effect on hyperglycemia, SGLT2i also have a variety of beneficial effects on cardiovascular disease. Experimental models of cardiovascular disease have shown that SGLT2i ameliorate the process of aging-related cardiovascular disease by inhibiting inflammation, reducing oxidative stress, and reversing endothelial dysfunction. In this review, we discuss the role of SGLT2i in aging-related cardiovascular disease and propose the use of SGLT2i to prevent and treat these conditions in older adults.
引用
收藏
页码：641 / 662
页数：22
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