Safety and Effectiveness of Maternal COVID-19 Vaccines Among Pregnant People and Infants

被引：22

作者：

Fleming-Dutra, Katherine E. ^{[1
]}

Zauche, Lauren Head ^{[2
]}

Roper, Lauren E. ^{[1
]}

Ellington, Sascha R. ^{[3
]}

Olson, Christine K. ^{[2
,4
]}

Sharma, Andrea J. ^{[2
,4
]}

Woodworth, Kate R. ^{[5
]}

Tepper, Naomi ^{[4
,5
]}

Havers, Fiona ^{[1
,4
]}

Oliver, Sara E. ^{[1
,4
]}

Twentyman, Evelyn ^{[1
]}

Jatlaoui, Tara C. ^{[4
,6
]}

机构：

[1] CDCP, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop H24-9, Atlanta, GA 30329 USA

[2] Div Ctr Dis Control & Prevent, Atlanta, GA USA

[3] CDCP, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA

[4] US Publ Hlth Serv Commissioned Corps, Atlanta, GA USA

[5] CDCP, Div Birth Defects & Infant Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

[6] CDCP, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

来源：

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2023年 / 50卷 / 02期

关键词：

COVID-19; vaccine; Pregnancy; Infants; mRNA vaccines; Vaccine effectiveness; Vaccine safety; Maternal vaccination; UNITED-STATES; IMMUNIZATION PRACTICES; ADVISORY-COMMITTEE; VACCINATION; RECOMMENDATIONS; HOSPITALIZATION; PREVENTION; ANTIBODIES;

D O I：

10.1016/j.ogc.2023.02.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In conclusion, pregnant people are at increased risk of severe disease and adverse pregnancy outcomes from COVID-19, but initial COVID-19 vaccine clinical trials excluded pregnant people. Postauthorization studies have been important to fill evi-dence gaps regarding COVID-19 vaccine safety and effectiveness in pregnant people and infants, and lessons learned from the COVID-19 pandemic include the importance of including pregnant people in clinical trials when possible. Evidence has consistently demonstrated that COVID-19 mRNA vaccines are safe when given during pregnancy for both pregnant people and infants, and COVID-19 mRNA vaccines protect pregnant people and their infants who are too young to receive COVID-19 vaccines. Monovalent vaccine effectiveness was lower during Omicron predominance, and bivalent vac-cines may improve protection against Omicron variants. Everyone, including people who are pregnant, breastfeeding, trying to get pregnant now, or might become preg-nant in the future, should stay up to date with recommended COVID-19 vaccines and get the recommended bivalent booster, when eligible.

引用

页码：279 / 297

页数：19

共 73 条

[1] Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants [J].

Abu-Raddad, Laith J. ;

Chemaitelly, Hiam ;

Butt, Adeel A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (02) :187-189

[2] Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis [J].

Allotey, John ;

Stallings, Elena ;

Bonet, Mercedes ;

Yap, Magnus ;

Chatterjee, Shaunak ;

Kew, Tania ;

Debenham, Luke ;

Llavall, Anna Clave ;

Dixit, Anushka ;

Zhou, Dengyi ;

Balaji, Rishab ;

Lee, Siang Ing ;

Qiu, Xiu ;

Yuan, Mingyang ;

Coomar, Dyuti ;

van Wely, Madelon ;

van Leeuwen, Elizabeth ;

Kostova, Elena ;

Kunst, Heinke ;

Khalil, Asma ;

Tiberi, Simon ;

Brizuela, Vanessa ;

Broutet, Nathalie ;

Kara, Edna ;

Kim, Caron Rahn ;

Thorson, Anna ;

Oladapo, Olufemi T. ;

Mofenson, Lynne ;

Zamora, Javier ;

Thangaratinam, Shakila .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 370

[3] Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms [J].

Atyeo, Caroline G. ;

Shook, Lydia L. ;

Brigida, Sara ;

De Guzman, Rose M. ;

Demidkin, Stepan ;

Muir, Cordelia ;

Akinwunmi, Babatunde ;

Baez, Arantxa Medina ;

McSweeney, Erin ;

Burns, Madeleine ;

Nayak, Ruhi ;

Kumar, Maya K. ;

Patel, Chinmay D. ;

Fialkowski, Allison ;

Cvrk, Dana ;

Goldfarb, Ilona T. ;

Yonker, Lael M. ;

Fasano, Alessio ;

Balazs, Alejandro B. ;

Elovitz, Michal A. ;

Gray, Kathryn J. ;

Alter, Galit ;

Edlow, Andrea G. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[4] Covid-19 vaccination in pregnancy [J].

Badell, Martina L. ;

Dude, Carolynn M. ;

Rasmussen, Sonja A. ;

Jamieson, Denise J. .

BMJ-BRITISH MEDICAL JOURNAL, 2022, 378

[5] COVID-19 vaccination during pregnancy: coverage and safety [J].

Blakeway, Helena ;

Prasad, Smriti ;

Kalafat, Erkan ;

Heath, Paul T. ;

Ladhani, Shamez N. ;

Le Doare, Kirsty ;

Magee, Laura A. ;

O'Brien, Pat ;

Rezvani, Arezou ;

von Dadelszen, Peter ;

Khalil, Asma .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2022, 226 (02) :236.e1-236.e14

[6] Early exploration of COVID-19 vaccination safety and effectiveness during pregnancy: interim descriptive data from a prospective observational study [J].

Bleicher, Inna ;

Kadour-Peero, Einav ;

Sagi-Dain, Lena ;

Sagi, Shlomi .

VACCINE, 2021, 39 (44) :6535-6538

[7] Impact of COVID-19 disease and COVID-19 vaccination on maternal or fetal inflammatory response, placental pathology, and perinatal outcomes [J].

Boelig, Rupsa C. ;

Aghai, Zubair H. ;

Chaudhury, Sidhartha ;

Kazan, Adina S. ;

Chan, Joanna S. Y. ;

Bergmann-Leitner, Elke .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2022, 227 (04) :652-656

[8] SARS-CoV-2 vaccine effectiveness in preventing confirmed infection in pregnant women [J].

Butt, Adeel A. ;

Chemaitelly, Hiam ;

Al Khal, Abdullatif ;

Coyle, Peter, V ;

Saleh, Huda ;

Kaleeckal, Anvar H. ;

Latif, Ali Nizar ;

Bertollini, Roberto ;

Abou-Samra, Abdul-Badi ;

Abu-Raddad, Laith J. .

JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (23)

[9] Association of COVID-19 Vaccination During Pregnancy With Incidence of SARS-CoV-2 Infection in Infants [J].

Carlsen, Ellen Oen ;

Magnus, Maria C. ;

Oakley, Laura ;

Fell, Deshayne B. ;

Greve-Isdahl, Margrethe ;

Kinge, Jonas Minet ;

Haberg, Siri E. .

JAMA INTERNAL MEDICINE, 2022, 182 (08) :825-831

[10]

Centers for Disease Control and Prevention, New CDC Data: COVID-19 Vaccination Safe for Pregnant People

← 1 2 3 4 5 6 7 8 →