Addition of the FTD Module to the Neuropsychiatric Inventory improves classification of frontotemporal dementia spectrum disorders

被引：3
作者：
Jiskoot, Lize C. [1 ,2 ,3 ,6 ]
Russell, Lucy L. [3 ]
Greaves, Caroline V. [3 ]
van Schaik, Esther [1 ,2 ]
van den Berg, Esther [1 ,2 ]
Poos, Jackie M. [1 ,2 ]
de Boer, Liset [1 ,2 ]
Donker Kaat, Laura [1 ,2 ,4 ]
Seelaar, Harro [1 ,2 ]
Pijnenburg, Yolande A. L. [5 ]
van Swieten, John C. [1 ,2 ]
Rohrer, Jonathan D. [3 ]
机构：
[1] Erasmus MC Univ, Dept Neurol, Med Ctr, Room NF-331,Dr Molenwaterpl 40, NL-3015 CE Rotterdam, Netherlands
[2] Erasmus MC Univ Med Ctr, Alzheimer Ctr Erasmus MC, Room NF-331, Dr Molenwaterpl 40, NL-3015 CE Rotterdam, Netherlands
[3] UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England
[4] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands
[5] Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
[6] Univ Coll London UCL, Natl Hosp Neurol & Neurosurg, Dementia Res Ctr DRC, 8-11 Queen Sq,Box 16, London WC1N, England
来源：
JOURNAL OF NEUROLOGY | 2023年 / 270卷 / 05期
基金：
英国医学研究理事会;
关键词：
Neuropsychiatric symptoms; Neuropsychiatric inventory; Dementia; FTD; Classification; BEHAVIORAL VARIANT; LOBAR DEGENERATION; ALZHEIMERS-DISEASE; DIAGNOSTIC-CRITERIA; FEATURES; SYMPTOMS; PSYCHOPATHOLOGY; RECOMMENDATIONS; SUBTYPES;
D O I：
10.1007/s00415-023-11596-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Most neuropsychiatric symptoms (NPS) common in frontotemporal dementia (FTD) are currently not part of the Neuropsychiatric Inventory (NPI). We piloted an FTD Module that included eight extra items to be used in conjunction with the NPI. Caregivers of patients with behavioural variant FTD (n = 49), primary progressive aphasia (PPA; n = 52), Alzheimer's dementia (AD; n = 41), psychiatric disorders (n = 18), presymptomatic mutation carriers (n = 58) and controls (n = 58) completed the NPI and FTD Module. We investigated (concurrent and construct) validity, factor structure and internal consistency of the NPI and FTD Module. We performed group comparisons on item prevalence, mean item and total NPI and NPI with FTD Module scores, and multinomial logistic regression to determine its classification abilities. We extracted four components, together explaining 64.1% of the total variance, of which the largest indicated the underlying dimension 'frontal-behavioural symptoms'. Whilst apathy (original NPI) occurred most frequently in AD, logopenic and non-fluent variant PPA, the most common NPS in behavioural variant FTD and semantic variant PPA were loss of sympathy/empathy and poor response to social/emotional cues (part of FTD Module). Patients with primary psychiatric disorders and behavioural variant FTD showed the most severe behavioural problems on both the NPI as well as the NPI with FTD Module. The NPI with FTD Module correctly classified more FTD patients than the NPI alone. By quantifying common NPS in FTD the NPI with FTD Module has large diagnostic potential. Future studies should investigate whether it can also prove a useful addition to the NPI in therapeutic trials.
引用
收藏
页码：2674 / 2687
页数：14
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