Association of Neutrophil-to-Lymphocyte Ratio with the Risk of Fatal Stroke Occurrence in Older Chinese

被引:2
作者
Hu, Zhi-bing [1 ,2 ]
Zhong, Qiong-qiong [1 ,2 ,3 ]
Lu, Ze-xiong [4 ]
Zhu, Feng [1 ,2 ]
机构
[1] Guangzhou Twelfth Peoples Hosp, Dept Internal Med, Guangzhou, Peoples R China
[2] Guangzhou Twelfth Peoples Hosp, Cent Lab, Guangzhou, Peoples R China
[3] Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou, Peoples R China
[4] Sanya Cent Hosp, Dept Internal Med, Sanya, Peoples R China
关键词
cohort study; stroke; ischaemic; haemorrhagic; neutrophil-to-lymphocyte ratio; MORTALITY; PREDICT; INFLAMMATION; INSIGHTS; IMPROVES; DISEASE;
D O I
10.1177/10760296221098720
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Associations of neutrophil-to-lymphocyte ratio (NLR) and its longitudinal change with risk of fatal strokes are unclear in older populations. Methods In this retrospective analysis, a total of 27,799 participants were included and followed up for a mean of 14.3 years (standard deviation = 3.2). 838 stroke deaths were recorded. Cox proportional hazards regression was used to assess associations of NLR with fatal strokes. Results Compared to those in the first quartile and after adjustment for a series of factors, the participants in the highest neutrophil quartile had an increased risk of fatal all stroke (adjusted hazard ratio (aHR) = 1.45, 95% confidence interval (CI), 1.18-1.79) and fatal ischaemic stroke (aHR = 1.58, 95% CI, 1.17-2.12). Restricted cubic splines showed an increased trend of relationship between the NLR and fatal all stroke. The participants with the highest NLR quartile had an increased risk of fatal all stroke (aHR = 1.52, 95% CI, 1.23-1.88) and fatal ischaemic stroke (aHR = 1.59, 95% CI, 1.13-2.26), respectively; Similar associations repeated after further C-reactive protein adjustment; a 21% and a 32% increased risk of fatal all stroke and fatal ischaemic stroke showed in a continuous variable model. Those in NLR change with 5% increase had a 70% increased risk of fatal all stroke (aHR = 1.70, 95%CI, 1.13-2.57), compared to those in stable (-5%similar to 5%). Conclusions Higher NLR was associated with an increased risk of fatal all stroke and fatal ischaemic stroke, and its longitudinal change increase of >= 5% was associated with an increased risk of fatal all stroke in a relatively healthy older population.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] Neutrophil-to-lymphocyte ratio, obesity, and breast cancer risk in Chinese population
    Fang, Qiong
    Tong, Yi-Wei
    Wang, Gen
    Zhang, Nan
    Chen, Wei-Guo
    Li, Ya-Fen
    Shen, Kun-Wei
    Wu, Bei-Wen
    Chen, Xiao-Song
    MEDICINE, 2018, 97 (30)
  • [22] Neutrophil-to-Lymphocyte ratio may have a role in the differential diagnosis of ischemic stroke
    Onder, Halil
    Cankurtaran, Mustafa
    Ozyurek, Ozge
    Arslan, Guven
    NEUROLOGY ASIA, 2020, 25 (02) : 93 - 101
  • [23] Nomogram Including Neutrophil-to-Lymphocyte Ratio for the Prediction of Stroke-Associated Infections
    Lan, Yan
    Sun, Wenzhe
    Chen, Yuxi
    Miao, Jinfeng
    Li, Guo
    Qiu, Xiuli
    Song, Xiaoyan
    Zhao, Xin
    Zhu, Zhou
    Fan, Yebin
    Zhu, Suiqiang
    FRONTIERS IN NEUROLOGY, 2020, 11
  • [24] Relationship of Neutrophil-to-Lymphocyte Ratio with Carotid Plaque Vulnerability and Occurrence of Vulnerable Carotid Plaque in Patients with Acute Ischemic Stroke
    Li, Xin
    Li, Jing
    Wu, Guode
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [25] Blood neutrophil-to-lymphocyte ratio as a risk factor in treatment for retinopathy of prematurity
    Obata, Shumpei
    Matsumoto, Riko
    Kakinoki, Masashi
    Sawada, Osamu
    Sawada, Tomoko
    Saishin, Yoshitsugu
    Yanagi, Takahide
    Maruo, Yoshihiro
    Ohji, Masahito
    GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2023, 261 (04) : 951 - 957
  • [26] Neutrophil-to-lymphocyte ratio and risk of lung cancer mortality in a low-risk population: A cohort study
    Kang, Jihoon
    Chang, Yoosoo
    Ahn, Jiin
    Oh, Sukjoong
    Koo, Dong-Hoe
    Lee, Yun-Gyoo
    Shin, Hocheol
    Ryu, Seungho
    INTERNATIONAL JOURNAL OF CANCER, 2019, 145 (12) : 3267 - 3275
  • [27] Association of Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with the Risk of Thromboembolism and Mortality in Patients with Cancer
    Grilz, Ella
    Posch, Florian
    Koenigsbruegge, Oliver
    Schwarzinger, Ilse
    Lang, Irene Marthe
    Marosi, Christine
    Pabinger, Ingrid
    Ay, Cihan
    THROMBOSIS AND HAEMOSTASIS, 2018, 118 (11) : 1875 - 1884
  • [28] Clinical Significance of Baseline Neutrophil-to-Lymphocyte Ratio in Patients With Ischemic Stroke or Hemorrhagic Stroke: An Updated Meta-Analysis
    Song, Si-Ying
    Zhao, Xiao-Xi
    Rajah, Gary
    Hua, Chang
    Kang, Rui-jun
    Han, Yi-peng
    Ding, Yu-chuan
    Meng, Ran
    FRONTIERS IN NEUROLOGY, 2019, 10
  • [29] The relationship between neutrophil-to-lymphocyte ratio and the first occurrence of pneumonia in peritoneal dialysis patients
    Zhang, Yujing
    Lai, Xiaochun
    Chen, Qinkai
    Zhan, Xiaojiang
    Long, Haibo
    Peng, Fenfen
    Zhang, Fengping
    Feng, Xiaoran
    Zhou, Qian
    Wu, Xianfeng
    Liu, Lingling
    Wang, Zebin
    Peng, Xuan
    Hu, Kaiyuan
    Wang, Dijing
    Guo, Guanhua
    Zeng, Yingsi
    Wen, Yueqiang
    Liang, Jianbo
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2020, 24 (09) : 770 - 778
  • [30] The association between platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and carotid artery stenosis and stroke following carotid endarterectomy
    Deser, Serkan Burc
    Yucel, Semih Murat
    Demirag, Mustafa Kemal
    Guclu, Muzaffer Murat
    Kolbakir, Fersat
    Keceligil, Hasan Tahsin
    VASCULAR, 2019, 27 (06) : 604 - 611