Systemic Therapy in Advanced Pleomorphic Liposarcoma: a Comprehensive Review

被引：1

作者：

Assi, Tarek ^{[1
]}

Ngo, Carine ^{[1
]}

Faron, Matthieu ^{[1
,2
]}

Verret, Benjamin ^{[1
]}

Levy, Antonin ^{[1
]}

Honore, Charles ^{[1
]}

Henon, Clemence ^{[1
]}

Le Pechoux, Cecile ^{[1
]}

Bahleda, Rastilav ^{[1
]}

Le Cesne, Axel ^{[1
]}

机构：

[1] Gustave Roussy Canc Campus, Dept Canc Med, Sarcoma Unit, 114 Rue Edouard Vailla, Villejuif, France

[2] Univ Paris Saclay, Equipe Labellisee Ligue Contre Canc, INSERM, Oncostat U1018, Villejuif, France

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2023年 / 24卷 / 11期

关键词：

Liposarcoma; Soft tissue; Sarcoma; Pleomorphic; Chemotherapy; SOFT-TISSUE SARCOMA; OPEN-LABEL; CLINICOPATHOLOGICAL ANALYSIS; METASTATIC LIPOSARCOMA; 1ST-LINE TREATMENT; SINGLE-ARM; PHASE-II; TRABECTEDIN; PAZOPANIB; DOXORUBICIN;

D O I：

10.1007/s11864-023-01139-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic approach of pleomorphic liposarcoma (PLPS), a rare high-grade subgroup of soft tissue sarcoma, is commonly extrapolated from the management of other LPS subtypes. Only published retrospective data on PLPS currently serve as a guide for oncologists without clear recommendations or specific guidelines. In the advanced setting, specific systemic therapy such as eribulin and trabectedin showed promising activity in comparison to conventional therapy (doxorubicin- and gemcitabine-based protocols), which currently remains the current standard of care at initial stages of the disease. The better understanding of soft tissue sarcoma (STS) pathophysiology and disease course has led to the development of adapted clinical trial designs for rare STS histotypes with specific treatment approach.

引用

页码：1598 / 1613

页数：16

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